Biodistribution and Molecular Studies on Orally Administered Nanoparticle-AON Complexes Encapsulated with Alginate Aiming at Inducing Dystrophin Rescue in mdx Mice

We have previously demonstrated that intraperitoneal injections of 2′-O-methyl-phosphorothioate (2′OMePS) antisense oligoribonucleotides adsorbed onto a cationic core-shell nanoparticles (NPs), termed ZM2, provoke dystrophin restoration in the muscles of mdx mice. The aim of the present work was to...

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Detalles Bibliográficos
Autores principales: Falzarano, Maria Sofia, Passarelli, Chiara, Bassi, Elena, Fabris, Marina, Perrone, Daniela, Sabatelli, Patrizia, Maraldi, Nadir M., Donà, Silvia, Selvatici, Rita, Bonaldo, Paolo, Sparnacci, Katia, Laus, Michele, Braghetta, Paola, Rimessi, Paola, Ferlini, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874323/
https://www.ncbi.nlm.nih.gov/pubmed/24392452
http://dx.doi.org/10.1155/2013/527418

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