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The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI
It has been proposed that two relatively independent cognitive control networks exist in the brain: the cingulo-opercular network (CO) and the fronto-parietal network (FP). Past work has shown that chronic brain lesions affect these networks independently. It remains unclear, however, how these two...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874542/ https://www.ncbi.nlm.nih.gov/pubmed/24416003 http://dx.doi.org/10.3389/fnsys.2013.00124 |
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author | Gratton, Caterina Lee, Taraz G. Nomura, Emi M. D'Esposito, Mark |
author_facet | Gratton, Caterina Lee, Taraz G. Nomura, Emi M. D'Esposito, Mark |
author_sort | Gratton, Caterina |
collection | PubMed |
description | It has been proposed that two relatively independent cognitive control networks exist in the brain: the cingulo-opercular network (CO) and the fronto-parietal network (FP). Past work has shown that chronic brain lesions affect these networks independently. It remains unclear, however, how these two networks are affected by acute brain disruptions. To examine this, we conducted a within-subject theta-burst transcranial magnetic stimulation (TBS) experiment in healthy individuals that targeted left anterior insula/frontal operculum (L aI/fO, a region in the CO network), left dorsolateral prefrontal cortex (L dlPFC, a region in the FP network), or left primary somatosensory cortex (L S1, an experimental control region). Functional connectivity (FC) was measured in resting state fMRI scans collected before and after continuous TBS on each day. We found that TBS was accompanied by generalized increases in network connectivity, especially FP network connectivity, after TBS to either region involved in cognitive control. Whole-brain analyses demonstrated that the L dlPFC and L aI/fO showed increased connectivity with regions in frontal, parietal, and cingulate cortex after TBS to either L dlPFC or L aI/fO, but not to L S1. These results suggest that acute disruption by TBS to cognitive control regions causes widespread changes in network connectivity not limited to the targeted networks. |
format | Online Article Text |
id | pubmed-3874542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38745422014-01-10 The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI Gratton, Caterina Lee, Taraz G. Nomura, Emi M. D'Esposito, Mark Front Syst Neurosci Neuroscience It has been proposed that two relatively independent cognitive control networks exist in the brain: the cingulo-opercular network (CO) and the fronto-parietal network (FP). Past work has shown that chronic brain lesions affect these networks independently. It remains unclear, however, how these two networks are affected by acute brain disruptions. To examine this, we conducted a within-subject theta-burst transcranial magnetic stimulation (TBS) experiment in healthy individuals that targeted left anterior insula/frontal operculum (L aI/fO, a region in the CO network), left dorsolateral prefrontal cortex (L dlPFC, a region in the FP network), or left primary somatosensory cortex (L S1, an experimental control region). Functional connectivity (FC) was measured in resting state fMRI scans collected before and after continuous TBS on each day. We found that TBS was accompanied by generalized increases in network connectivity, especially FP network connectivity, after TBS to either region involved in cognitive control. Whole-brain analyses demonstrated that the L dlPFC and L aI/fO showed increased connectivity with regions in frontal, parietal, and cingulate cortex after TBS to either L dlPFC or L aI/fO, but not to L S1. These results suggest that acute disruption by TBS to cognitive control regions causes widespread changes in network connectivity not limited to the targeted networks. Frontiers Media S.A. 2013-12-30 /pmc/articles/PMC3874542/ /pubmed/24416003 http://dx.doi.org/10.3389/fnsys.2013.00124 Text en Copyright © 2013 Gratton, Lee, Nomura and D'Esposito. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Gratton, Caterina Lee, Taraz G. Nomura, Emi M. D'Esposito, Mark The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI |
title | The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI |
title_full | The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI |
title_fullStr | The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI |
title_full_unstemmed | The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI |
title_short | The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI |
title_sort | effect of theta-burst tms on cognitive control networks measured with resting state fmri |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874542/ https://www.ncbi.nlm.nih.gov/pubmed/24416003 http://dx.doi.org/10.3389/fnsys.2013.00124 |
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