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Long non-coding RNAs in neurodevelopmental disorders

Recent studies have emphasized an important role for long non-coding RNAs (lncRNA) in epigenetic regulation, development, and disease. Despite growing interest in lncRNAs, the mechanisms by which lncRNAs control cellular processes are still elusive. Improved understanding of these mechanisms is crit...

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Autores principales: van de Vondervoort, Ilse I. G. M., Gordebeke, Peter M., Khoshab, Nima, Tiesinga, Paul H. E., Buitelaar, Jan K., Kozicz, Tamas, Aschrafi, Armaz, Glennon, Jeffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874560/
https://www.ncbi.nlm.nih.gov/pubmed/24415997
http://dx.doi.org/10.3389/fnmol.2013.00053
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author van de Vondervoort, Ilse I. G. M.
Gordebeke, Peter M.
Khoshab, Nima
Tiesinga, Paul H. E.
Buitelaar, Jan K.
Kozicz, Tamas
Aschrafi, Armaz
Glennon, Jeffrey C.
author_facet van de Vondervoort, Ilse I. G. M.
Gordebeke, Peter M.
Khoshab, Nima
Tiesinga, Paul H. E.
Buitelaar, Jan K.
Kozicz, Tamas
Aschrafi, Armaz
Glennon, Jeffrey C.
author_sort van de Vondervoort, Ilse I. G. M.
collection PubMed
description Recent studies have emphasized an important role for long non-coding RNAs (lncRNA) in epigenetic regulation, development, and disease. Despite growing interest in lncRNAs, the mechanisms by which lncRNAs control cellular processes are still elusive. Improved understanding of these mechanisms is critical, because the majority of the mammalian genome is transcribed, in most cases resulting in non-coding RNA products. Recent studies have suggested the involvement of lncRNA in neurobehavioral and neurodevelopmental disorders, highlighting the functional importance of this subclass of brain-enriched RNAs. Impaired expression of lnRNAs has been implicated in several forms of intellectual disability disorders. However, the role of this family of RNAs in cognitive function is largely unknown. Here we provide an overview of recently identified mechanisms of neuronal development involving lncRNAs, and the consequences of lncRNA deregulation for neurodevelopmental disorders.
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spelling pubmed-38745602014-01-10 Long non-coding RNAs in neurodevelopmental disorders van de Vondervoort, Ilse I. G. M. Gordebeke, Peter M. Khoshab, Nima Tiesinga, Paul H. E. Buitelaar, Jan K. Kozicz, Tamas Aschrafi, Armaz Glennon, Jeffrey C. Front Mol Neurosci Neuroscience Recent studies have emphasized an important role for long non-coding RNAs (lncRNA) in epigenetic regulation, development, and disease. Despite growing interest in lncRNAs, the mechanisms by which lncRNAs control cellular processes are still elusive. Improved understanding of these mechanisms is critical, because the majority of the mammalian genome is transcribed, in most cases resulting in non-coding RNA products. Recent studies have suggested the involvement of lncRNA in neurobehavioral and neurodevelopmental disorders, highlighting the functional importance of this subclass of brain-enriched RNAs. Impaired expression of lnRNAs has been implicated in several forms of intellectual disability disorders. However, the role of this family of RNAs in cognitive function is largely unknown. Here we provide an overview of recently identified mechanisms of neuronal development involving lncRNAs, and the consequences of lncRNA deregulation for neurodevelopmental disorders. Frontiers Media S.A. 2013-12-30 /pmc/articles/PMC3874560/ /pubmed/24415997 http://dx.doi.org/10.3389/fnmol.2013.00053 Text en Copyright © 2013 van de Vondervoort, Gordebeke, Khoshab, Tiesinga, Buitelaar, Kozicz, Aschrafi and Glennon. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
van de Vondervoort, Ilse I. G. M.
Gordebeke, Peter M.
Khoshab, Nima
Tiesinga, Paul H. E.
Buitelaar, Jan K.
Kozicz, Tamas
Aschrafi, Armaz
Glennon, Jeffrey C.
Long non-coding RNAs in neurodevelopmental disorders
title Long non-coding RNAs in neurodevelopmental disorders
title_full Long non-coding RNAs in neurodevelopmental disorders
title_fullStr Long non-coding RNAs in neurodevelopmental disorders
title_full_unstemmed Long non-coding RNAs in neurodevelopmental disorders
title_short Long non-coding RNAs in neurodevelopmental disorders
title_sort long non-coding rnas in neurodevelopmental disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874560/
https://www.ncbi.nlm.nih.gov/pubmed/24415997
http://dx.doi.org/10.3389/fnmol.2013.00053
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