Functional reconstitution of the mitochondrial Ca(2+)/H(+) antiporter Letm1

The leucine zipper, EF hand–containing transmembrane protein 1 (Letm1) gene encodes a mitochondrial inner membrane protein, whose depletion severely perturbs mitochondrial Ca(2+) and K(+) homeostasis. Here we expressed, purified, and reconstituted human Letm1 protein in liposomes. Using Ca(2+) fluor...

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Detalles Bibliográficos
Autores principales: Tsai, Ming-Feng, Jiang, Dawei, Zhao, Linlin, Clapham, David, Miller, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874562/
https://www.ncbi.nlm.nih.gov/pubmed/24344246
http://dx.doi.org/10.1085/jgp.201311096

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