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Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

OBJECTIVE: Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozapine. METHOD: In this paper, we report on four cases in which adjunctive therapy...

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Detalles Bibliográficos
Autores principales: Eryılmaz, Gül, Hızlı Sayar, Gökben, Ozten, Eylem, Gögcegöz Gül, Işıl, Karamustafalıoğlu, Oğuz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874630/
https://www.ncbi.nlm.nih.gov/pubmed/24330737
http://dx.doi.org/10.1186/1744-859X-12-40
Descripción
Sumario:OBJECTIVE: Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozapine. METHOD: In this paper, we report on four cases in which adjunctive therapy with aripiprazole was tested to alleviate obsessive-compulsive symptoms in schizophrenia. RESULTS: All four patients had a significant improvement in obsessive-compulsive symptoms. The combination of clozapine and aripiprazole was well tolerated. CONCLUSION: This case series demonstrates the clinical efficacy of aripiprazole adjunctive therapy with clozapine in schizophrenic patients with comorbid obsessive-compulsive symptoms. Larger-sampled and controlled studies are required in order to test and confirm these observations.