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Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
BACKGROUND: The gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to pollutants (such as heavy metals) can also impair various physiological function...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874687/ https://www.ncbi.nlm.nih.gov/pubmed/24325943 http://dx.doi.org/10.1186/2050-6511-14-62 |
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author | Breton, Jérôme Massart, Sébastien Vandamme, Peter De Brandt, Evie Pot, Bruno Foligné, Benoît |
author_facet | Breton, Jérôme Massart, Sébastien Vandamme, Peter De Brandt, Evie Pot, Bruno Foligné, Benoît |
author_sort | Breton, Jérôme |
collection | PubMed |
description | BACKGROUND: The gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to pollutants (such as heavy metals) can also impair various physiological functions for good health. Here, we studied the impact of up to 8 weeks of oral lead and cadmium ingestion on the composition of the murine intestinal microbiome. RESULTS: Pyrosequencing of 16S RNA sequences revealed minor but specific changes in bacterial commensal communities (at both family and genus levels) following oral exposure to the heavy metals, with notably low numbers of Lachnospiraceae and high numbers levels of Lactobacillaceae and Erysipelotrichaceacae (mainly due to changes in Turicibacter spp), relative to control animals. CONCLUSIONS: Non-absorbed heavy metals have a direct impact on the gut microbiota. In turn, this may impact the alimentary tract and overall gut homeostasis. Our results may enable more accurate assessment of the risk of intestinal disease associated with heavy metal ingestion. |
format | Online Article Text |
id | pubmed-3874687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38746872013-12-31 Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome Breton, Jérôme Massart, Sébastien Vandamme, Peter De Brandt, Evie Pot, Bruno Foligné, Benoît BMC Pharmacol Toxicol Research Article BACKGROUND: The gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to pollutants (such as heavy metals) can also impair various physiological functions for good health. Here, we studied the impact of up to 8 weeks of oral lead and cadmium ingestion on the composition of the murine intestinal microbiome. RESULTS: Pyrosequencing of 16S RNA sequences revealed minor but specific changes in bacterial commensal communities (at both family and genus levels) following oral exposure to the heavy metals, with notably low numbers of Lachnospiraceae and high numbers levels of Lactobacillaceae and Erysipelotrichaceacae (mainly due to changes in Turicibacter spp), relative to control animals. CONCLUSIONS: Non-absorbed heavy metals have a direct impact on the gut microbiota. In turn, this may impact the alimentary tract and overall gut homeostasis. Our results may enable more accurate assessment of the risk of intestinal disease associated with heavy metal ingestion. BioMed Central 2013-12-11 /pmc/articles/PMC3874687/ /pubmed/24325943 http://dx.doi.org/10.1186/2050-6511-14-62 Text en Copyright © 2013 Breton et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Breton, Jérôme Massart, Sébastien Vandamme, Peter De Brandt, Evie Pot, Bruno Foligné, Benoît Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome |
title | Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome |
title_full | Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome |
title_fullStr | Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome |
title_full_unstemmed | Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome |
title_short | Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome |
title_sort | ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874687/ https://www.ncbi.nlm.nih.gov/pubmed/24325943 http://dx.doi.org/10.1186/2050-6511-14-62 |
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