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Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome

BACKGROUND: The gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to pollutants (such as heavy metals) can also impair various physiological function...

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Autores principales: Breton, Jérôme, Massart, Sébastien, Vandamme, Peter, De Brandt, Evie, Pot, Bruno, Foligné, Benoît
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874687/
https://www.ncbi.nlm.nih.gov/pubmed/24325943
http://dx.doi.org/10.1186/2050-6511-14-62
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author Breton, Jérôme
Massart, Sébastien
Vandamme, Peter
De Brandt, Evie
Pot, Bruno
Foligné, Benoît
author_facet Breton, Jérôme
Massart, Sébastien
Vandamme, Peter
De Brandt, Evie
Pot, Bruno
Foligné, Benoît
author_sort Breton, Jérôme
collection PubMed
description BACKGROUND: The gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to pollutants (such as heavy metals) can also impair various physiological functions for good health. Here, we studied the impact of up to 8 weeks of oral lead and cadmium ingestion on the composition of the murine intestinal microbiome. RESULTS: Pyrosequencing of 16S RNA sequences revealed minor but specific changes in bacterial commensal communities (at both family and genus levels) following oral exposure to the heavy metals, with notably low numbers of Lachnospiraceae and high numbers levels of Lactobacillaceae and Erysipelotrichaceacae (mainly due to changes in Turicibacter spp), relative to control animals. CONCLUSIONS: Non-absorbed heavy metals have a direct impact on the gut microbiota. In turn, this may impact the alimentary tract and overall gut homeostasis. Our results may enable more accurate assessment of the risk of intestinal disease associated with heavy metal ingestion.
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spelling pubmed-38746872013-12-31 Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome Breton, Jérôme Massart, Sébastien Vandamme, Peter De Brandt, Evie Pot, Bruno Foligné, Benoît BMC Pharmacol Toxicol Research Article BACKGROUND: The gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to pollutants (such as heavy metals) can also impair various physiological functions for good health. Here, we studied the impact of up to 8 weeks of oral lead and cadmium ingestion on the composition of the murine intestinal microbiome. RESULTS: Pyrosequencing of 16S RNA sequences revealed minor but specific changes in bacterial commensal communities (at both family and genus levels) following oral exposure to the heavy metals, with notably low numbers of Lachnospiraceae and high numbers levels of Lactobacillaceae and Erysipelotrichaceacae (mainly due to changes in Turicibacter spp), relative to control animals. CONCLUSIONS: Non-absorbed heavy metals have a direct impact on the gut microbiota. In turn, this may impact the alimentary tract and overall gut homeostasis. Our results may enable more accurate assessment of the risk of intestinal disease associated with heavy metal ingestion. BioMed Central 2013-12-11 /pmc/articles/PMC3874687/ /pubmed/24325943 http://dx.doi.org/10.1186/2050-6511-14-62 Text en Copyright © 2013 Breton et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Breton, Jérôme
Massart, Sébastien
Vandamme, Peter
De Brandt, Evie
Pot, Bruno
Foligné, Benoît
Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
title Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
title_full Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
title_fullStr Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
title_full_unstemmed Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
title_short Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
title_sort ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874687/
https://www.ncbi.nlm.nih.gov/pubmed/24325943
http://dx.doi.org/10.1186/2050-6511-14-62
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