Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design

BACKGROUND: Randomized control trials (RCTs) stopped early for benefit (truncated RCTs) are increasingly common and, on average, overestimate the relative magnitude of benefit by approximately 30%. Investigators stop trials early when they consider it is no longer ethical to enroll patients in a con...

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Detalles Bibliográficos
Autores principales: Prutsky, Gabriela J, Domecq, Juan Pablo, Erwin, Patricia J, Briel, Matthias, Montori, Victor M, Akl, Elie A, Meerpohl, Joerg J, Bassler, Dirk, Schandelmaier, Stefan, Walter, Stephen D, Zhou, Qi, Coello, Pablo Alonso, Moja, Lorenzo, Walter, Martin, Thorlund, Kristian, Glasziou, Paul, Kunz, Regina, Ferreira-Gonzalez, Ignacio, Busse, Jason, Sun, Xin, Kristiansen, Annette, Kasenda, Benjamin, Qasim-Agha, Osama, Pagano, Gennaro, Pardo-Hernandez, Hector, Urrutia, Gerard, Murad, Mohammad Hassan, Guyatt, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874848/
https://www.ncbi.nlm.nih.gov/pubmed/24131702
http://dx.doi.org/10.1186/1745-6215-14-335

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