Cargando…

Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery

PURPOSE: Dexmedetomidine, a potent selective α2-adrenergic agonist, produces sedation and analgesia. This study was conducted to assess the effect of dexmedetomidine infusion on sevoflurane requirements, recovery profiles, and emergence agitation in children undergoing ambulatory surgery. MATERIALS...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Na Young, Kim, So Yeon, Yoon, Hye Jin, Kil, Hae Keum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874907/
https://www.ncbi.nlm.nih.gov/pubmed/24339309
http://dx.doi.org/10.3349/ymj.2014.55.1.209
_version_ 1782297286181650432
author Kim, Na Young
Kim, So Yeon
Yoon, Hye Jin
Kil, Hae Keum
author_facet Kim, Na Young
Kim, So Yeon
Yoon, Hye Jin
Kil, Hae Keum
author_sort Kim, Na Young
collection PubMed
description PURPOSE: Dexmedetomidine, a potent selective α2-adrenergic agonist, produces sedation and analgesia. This study was conducted to assess the effect of dexmedetomidine infusion on sevoflurane requirements, recovery profiles, and emergence agitation in children undergoing ambulatory surgery. MATERIALS AND METHODS: Forty children undergoing ambulatory hernioplasty or orchiopexy were randomized into two groups. The dexmedetomidine group (Group D, n=20) received dexmedetomidine 1 µg/kg, followed by 0.1 µg/kg/h until the end of surgery, whereas the saline group (Group S, n=20) received volume-matched normal saline. Sevoflurane was used for induction and maintenance of anesthesia and caudal block was performed in all children. End-tidal sevoflurane concentration (ET-sevo), the incidence of emergence agitation, pain scores, and sedation scores were recorded. Hemodynamic changes and other adverse effects were assessed in the perioperative period. RESULTS: ET-sevo of Group D was significantly reduced in 23.8-67% compared to Group S during surgery. The incidence of emergence agitation was lower in Group D than in Group S (5% vs. 55%, p=0.001). Postoperative pain was comparable, and discharge time was not different between the groups. Mean arterial pressure and heart rate were significantly lower in Group D during surgery. CONCLUSION: Intraoperative infusion of dexmedetomidine reduced sevoflurane requirements and decreased emergence agitation without delaying discharge in children undergoing ambulatory surgery. However, caution should be taken in regard to bradycardia and hypotension.
format Online
Article
Text
id pubmed-3874907
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Yonsei University College of Medicine
record_format MEDLINE/PubMed
spelling pubmed-38749072014-01-01 Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery Kim, Na Young Kim, So Yeon Yoon, Hye Jin Kil, Hae Keum Yonsei Med J Original Article PURPOSE: Dexmedetomidine, a potent selective α2-adrenergic agonist, produces sedation and analgesia. This study was conducted to assess the effect of dexmedetomidine infusion on sevoflurane requirements, recovery profiles, and emergence agitation in children undergoing ambulatory surgery. MATERIALS AND METHODS: Forty children undergoing ambulatory hernioplasty or orchiopexy were randomized into two groups. The dexmedetomidine group (Group D, n=20) received dexmedetomidine 1 µg/kg, followed by 0.1 µg/kg/h until the end of surgery, whereas the saline group (Group S, n=20) received volume-matched normal saline. Sevoflurane was used for induction and maintenance of anesthesia and caudal block was performed in all children. End-tidal sevoflurane concentration (ET-sevo), the incidence of emergence agitation, pain scores, and sedation scores were recorded. Hemodynamic changes and other adverse effects were assessed in the perioperative period. RESULTS: ET-sevo of Group D was significantly reduced in 23.8-67% compared to Group S during surgery. The incidence of emergence agitation was lower in Group D than in Group S (5% vs. 55%, p=0.001). Postoperative pain was comparable, and discharge time was not different between the groups. Mean arterial pressure and heart rate were significantly lower in Group D during surgery. CONCLUSION: Intraoperative infusion of dexmedetomidine reduced sevoflurane requirements and decreased emergence agitation without delaying discharge in children undergoing ambulatory surgery. However, caution should be taken in regard to bradycardia and hypotension. Yonsei University College of Medicine 2014-01-01 2013-11-29 /pmc/articles/PMC3874907/ /pubmed/24339309 http://dx.doi.org/10.3349/ymj.2014.55.1.209 Text en © Copyright: Yonsei University College of Medicine 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Na Young
Kim, So Yeon
Yoon, Hye Jin
Kil, Hae Keum
Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery
title Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery
title_full Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery
title_fullStr Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery
title_full_unstemmed Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery
title_short Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery
title_sort effect of dexmedetomidine on sevoflurane requirements and emergence agitation in children undergoing ambulatory surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874907/
https://www.ncbi.nlm.nih.gov/pubmed/24339309
http://dx.doi.org/10.3349/ymj.2014.55.1.209
work_keys_str_mv AT kimnayoung effectofdexmedetomidineonsevofluranerequirementsandemergenceagitationinchildrenundergoingambulatorysurgery
AT kimsoyeon effectofdexmedetomidineonsevofluranerequirementsandemergenceagitationinchildrenundergoingambulatorysurgery
AT yoonhyejin effectofdexmedetomidineonsevofluranerequirementsandemergenceagitationinchildrenundergoingambulatorysurgery
AT kilhaekeum effectofdexmedetomidineonsevofluranerequirementsandemergenceagitationinchildrenundergoingambulatorysurgery