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Melanoma: From Melanocyte to Genetic Alterations and Clinical Options
Metastatic melanoma remained for decades without any effective treatment and was thus considered as a paradigm of cancer resistance. Recent progress with understanding of the molecular mechanisms underlying melanoma initiation and progression revealed that melanomas are genetically and phenotypicall...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874946/ https://www.ncbi.nlm.nih.gov/pubmed/24416617 http://dx.doi.org/10.1155/2013/635203 |
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author | Bertolotto, Corine |
author_facet | Bertolotto, Corine |
author_sort | Bertolotto, Corine |
collection | PubMed |
description | Metastatic melanoma remained for decades without any effective treatment and was thus considered as a paradigm of cancer resistance. Recent progress with understanding of the molecular mechanisms underlying melanoma initiation and progression revealed that melanomas are genetically and phenotypically heterogeneous tumors. This recent progress has allowed for the development of treatment able to improve for the first time the overall disease-free survival of metastatic melanoma patients. However, clinical responses are still either too transient or limited to restricted patient subsets. The complete cure of metastatic melanoma therefore remains a challenge in the clinic. This review aims to present the recent knowledge and discoveries of the molecular mechanisms involved in melanoma pathogenesis and their exploitation into clinic that have recently facilitated bench to bedside advances. |
format | Online Article Text |
id | pubmed-3874946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38749462014-01-12 Melanoma: From Melanocyte to Genetic Alterations and Clinical Options Bertolotto, Corine Scientifica (Cairo) Review Article Metastatic melanoma remained for decades without any effective treatment and was thus considered as a paradigm of cancer resistance. Recent progress with understanding of the molecular mechanisms underlying melanoma initiation and progression revealed that melanomas are genetically and phenotypically heterogeneous tumors. This recent progress has allowed for the development of treatment able to improve for the first time the overall disease-free survival of metastatic melanoma patients. However, clinical responses are still either too transient or limited to restricted patient subsets. The complete cure of metastatic melanoma therefore remains a challenge in the clinic. This review aims to present the recent knowledge and discoveries of the molecular mechanisms involved in melanoma pathogenesis and their exploitation into clinic that have recently facilitated bench to bedside advances. Hindawi Publishing Corporation 2013 2013-12-12 /pmc/articles/PMC3874946/ /pubmed/24416617 http://dx.doi.org/10.1155/2013/635203 Text en Copyright © 2013 Corine Bertolotto. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bertolotto, Corine Melanoma: From Melanocyte to Genetic Alterations and Clinical Options |
title | Melanoma: From Melanocyte to Genetic Alterations and Clinical Options |
title_full | Melanoma: From Melanocyte to Genetic Alterations and Clinical Options |
title_fullStr | Melanoma: From Melanocyte to Genetic Alterations and Clinical Options |
title_full_unstemmed | Melanoma: From Melanocyte to Genetic Alterations and Clinical Options |
title_short | Melanoma: From Melanocyte to Genetic Alterations and Clinical Options |
title_sort | melanoma: from melanocyte to genetic alterations and clinical options |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874946/ https://www.ncbi.nlm.nih.gov/pubmed/24416617 http://dx.doi.org/10.1155/2013/635203 |
work_keys_str_mv | AT bertolottocorine melanomafrommelanocytetogeneticalterationsandclinicaloptions |