Frequent truncating mutations of STAG2 in bladder cancer

Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that ST...

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Detalles Bibliográficos
Autores principales: Solomon, David A., Kim, Jung-Sik, Bondaruk, Jolanta, Shariat, Shahrokh F., Wang, Zeng-Feng, Elkahloun, Abdel G., Ozawa, Tomoko, Gerard, Julia, Zhuang, DaZhong, Zhang, Shizhen, Navai, Neema, Siefker-Radtker, Arleen, Phillips, Joanna J., Robinson, Brian D., Rubin, Mark A., Volkmer, Björn, Hautmann, Richard, Küfer, Rainer, Hogendoorn, Pancras C. W., Netto, George, Theodorescu, Dan, James, C. David, Czerniak, Bogdan, Miettinen, Markku, Waldman, Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875130/
https://www.ncbi.nlm.nih.gov/pubmed/24121789
http://dx.doi.org/10.1038/ng.2800
Descripción
Sumario:Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 plays a role in controlling chromosome number but not proliferation of bladder cancer cells. These findings identify STAG2 as among the most commonly mutated genes in bladder cancer discovered to date.

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