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Frequent truncating mutations of STAG2 in bladder cancer
Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that ST...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875130/ https://www.ncbi.nlm.nih.gov/pubmed/24121789 http://dx.doi.org/10.1038/ng.2800 |
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| author | Solomon, David A. Kim, Jung-Sik Bondaruk, Jolanta Shariat, Shahrokh F. Wang, Zeng-Feng Elkahloun, Abdel G. Ozawa, Tomoko Gerard, Julia Zhuang, DaZhong Zhang, Shizhen Navai, Neema Siefker-Radtker, Arleen Phillips, Joanna J. Robinson, Brian D. Rubin, Mark A. Volkmer, Björn Hautmann, Richard Küfer, Rainer Hogendoorn, Pancras C. W. Netto, George Theodorescu, Dan James, C. David Czerniak, Bogdan Miettinen, Markku Waldman, Todd |
| author_facet | Solomon, David A. Kim, Jung-Sik Bondaruk, Jolanta Shariat, Shahrokh F. Wang, Zeng-Feng Elkahloun, Abdel G. Ozawa, Tomoko Gerard, Julia Zhuang, DaZhong Zhang, Shizhen Navai, Neema Siefker-Radtker, Arleen Phillips, Joanna J. Robinson, Brian D. Rubin, Mark A. Volkmer, Björn Hautmann, Richard Küfer, Rainer Hogendoorn, Pancras C. W. Netto, George Theodorescu, Dan James, C. David Czerniak, Bogdan Miettinen, Markku Waldman, Todd |
| author_sort | Solomon, David A. |
| collection | PubMed |
| description | Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 plays a role in controlling chromosome number but not proliferation of bladder cancer cells. These findings identify STAG2 as among the most commonly mutated genes in bladder cancer discovered to date. |
| format | Online Article Text |
| id | pubmed-3875130 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-38751302014-06-01 Frequent truncating mutations of STAG2 in bladder cancer Solomon, David A. Kim, Jung-Sik Bondaruk, Jolanta Shariat, Shahrokh F. Wang, Zeng-Feng Elkahloun, Abdel G. Ozawa, Tomoko Gerard, Julia Zhuang, DaZhong Zhang, Shizhen Navai, Neema Siefker-Radtker, Arleen Phillips, Joanna J. Robinson, Brian D. Rubin, Mark A. Volkmer, Björn Hautmann, Richard Küfer, Rainer Hogendoorn, Pancras C. W. Netto, George Theodorescu, Dan James, C. David Czerniak, Bogdan Miettinen, Markku Waldman, Todd Nat Genet Article Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 plays a role in controlling chromosome number but not proliferation of bladder cancer cells. These findings identify STAG2 as among the most commonly mutated genes in bladder cancer discovered to date. 2013-10-13 2013-12 /pmc/articles/PMC3875130/ /pubmed/24121789 http://dx.doi.org/10.1038/ng.2800 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Solomon, David A. Kim, Jung-Sik Bondaruk, Jolanta Shariat, Shahrokh F. Wang, Zeng-Feng Elkahloun, Abdel G. Ozawa, Tomoko Gerard, Julia Zhuang, DaZhong Zhang, Shizhen Navai, Neema Siefker-Radtker, Arleen Phillips, Joanna J. Robinson, Brian D. Rubin, Mark A. Volkmer, Björn Hautmann, Richard Küfer, Rainer Hogendoorn, Pancras C. W. Netto, George Theodorescu, Dan James, C. David Czerniak, Bogdan Miettinen, Markku Waldman, Todd Frequent truncating mutations of STAG2 in bladder cancer |
| title | Frequent truncating mutations of STAG2 in bladder cancer |
| title_full | Frequent truncating mutations of STAG2 in bladder cancer |
| title_fullStr | Frequent truncating mutations of STAG2 in bladder cancer |
| title_full_unstemmed | Frequent truncating mutations of STAG2 in bladder cancer |
| title_short | Frequent truncating mutations of STAG2 in bladder cancer |
| title_sort | frequent truncating mutations of stag2 in bladder cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875130/ https://www.ncbi.nlm.nih.gov/pubmed/24121789 http://dx.doi.org/10.1038/ng.2800 |
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