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Characterization of IGF-II Isoforms in Binge Eating Disorder and Its Group Psychological Treatment
INTRO: Binge eating disorder (BED) affects 3.5% of the population and is characterized by binge eating for at least 2 days a week for 6 months. Treatment options include cognitive behavioral therapy, interpersonal psychotherapy, and pharmacotherapy which are associated with varied success. Little is...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875431/ https://www.ncbi.nlm.nih.gov/pubmed/24386136 http://dx.doi.org/10.1371/journal.pone.0083019 |
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author | Tasca, Giorgio Lelievre, Julien Yockell Qiu, Qing Ritchie, Kerri Little, John Trinneer, Anne Barber, Ann Chyurlia, Livia Bissada, Hany Gruslin, Andreé |
author_facet | Tasca, Giorgio Lelievre, Julien Yockell Qiu, Qing Ritchie, Kerri Little, John Trinneer, Anne Barber, Ann Chyurlia, Livia Bissada, Hany Gruslin, Andreé |
author_sort | Tasca, Giorgio |
collection | PubMed |
description | INTRO: Binge eating disorder (BED) affects 3.5% of the population and is characterized by binge eating for at least 2 days a week for 6 months. Treatment options include cognitive behavioral therapy, interpersonal psychotherapy, and pharmacotherapy which are associated with varied success. Little is known about the biology of BED. Since there is evidence that the insulin like growth factor system is implicated in regulation of body weight, insulin sensitivity and feeding behavior, we speculated it may be involved in BED. METHODS: A cross-sectional comparison was made between three groups of women: overweight with BED, overweight without BED and normal weight without BED. Women were assigned to Group Psychodynamic Interpersonal Psychotherapy. Blood was collected before therapy, at completion and at 6months follow up for evaluation of IGF-II using Western blot. RESULTS: 97 overweight women with BED contributed to the cross-sectional comparison. The two control groups comprised 53 overweight women without BED, and 50 age matched normal weight women without BED. Obese women had significantly lower Big IGF-II than normal weight women, p = .028; Overweight women with BED had higher Mature IGF-II than normal weight women, p<.05. Big IGF-II showed a significant decreasing slope from pre- to post- to six months post-group psychological treatment, unrelated to changes in BMI (p = .008). CONCLUSION: Levels of IGF-II isoforms differed significantly between overweight and normal weight women. Overweight women with BED display abnormal levels of circulating IGF-II isoforms. BED is characterized by elevated mature IGF-II, an isoform shown to carry significant bioactivity. This finding is not related to BMI or to changes in body weight. The results also provide preliminary evidence that BIG IGF-II is sensitive to change due to group psychological treatment. We suggest that abnormalities in IGF-II processing may be involved in the neurobiology of BED. |
format | Online Article Text |
id | pubmed-3875431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38754312014-01-02 Characterization of IGF-II Isoforms in Binge Eating Disorder and Its Group Psychological Treatment Tasca, Giorgio Lelievre, Julien Yockell Qiu, Qing Ritchie, Kerri Little, John Trinneer, Anne Barber, Ann Chyurlia, Livia Bissada, Hany Gruslin, Andreé PLoS One Research Article INTRO: Binge eating disorder (BED) affects 3.5% of the population and is characterized by binge eating for at least 2 days a week for 6 months. Treatment options include cognitive behavioral therapy, interpersonal psychotherapy, and pharmacotherapy which are associated with varied success. Little is known about the biology of BED. Since there is evidence that the insulin like growth factor system is implicated in regulation of body weight, insulin sensitivity and feeding behavior, we speculated it may be involved in BED. METHODS: A cross-sectional comparison was made between three groups of women: overweight with BED, overweight without BED and normal weight without BED. Women were assigned to Group Psychodynamic Interpersonal Psychotherapy. Blood was collected before therapy, at completion and at 6months follow up for evaluation of IGF-II using Western blot. RESULTS: 97 overweight women with BED contributed to the cross-sectional comparison. The two control groups comprised 53 overweight women without BED, and 50 age matched normal weight women without BED. Obese women had significantly lower Big IGF-II than normal weight women, p = .028; Overweight women with BED had higher Mature IGF-II than normal weight women, p<.05. Big IGF-II showed a significant decreasing slope from pre- to post- to six months post-group psychological treatment, unrelated to changes in BMI (p = .008). CONCLUSION: Levels of IGF-II isoforms differed significantly between overweight and normal weight women. Overweight women with BED display abnormal levels of circulating IGF-II isoforms. BED is characterized by elevated mature IGF-II, an isoform shown to carry significant bioactivity. This finding is not related to BMI or to changes in body weight. The results also provide preliminary evidence that BIG IGF-II is sensitive to change due to group psychological treatment. We suggest that abnormalities in IGF-II processing may be involved in the neurobiology of BED. Public Library of Science 2013-12-30 /pmc/articles/PMC3875431/ /pubmed/24386136 http://dx.doi.org/10.1371/journal.pone.0083019 Text en © 2013 Tasca et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Tasca, Giorgio Lelievre, Julien Yockell Qiu, Qing Ritchie, Kerri Little, John Trinneer, Anne Barber, Ann Chyurlia, Livia Bissada, Hany Gruslin, Andreé Characterization of IGF-II Isoforms in Binge Eating Disorder and Its Group Psychological Treatment |
title | Characterization of IGF-II Isoforms in Binge Eating Disorder and Its Group Psychological Treatment |
title_full | Characterization of IGF-II Isoforms in Binge Eating Disorder and Its Group Psychological Treatment |
title_fullStr | Characterization of IGF-II Isoforms in Binge Eating Disorder and Its Group Psychological Treatment |
title_full_unstemmed | Characterization of IGF-II Isoforms in Binge Eating Disorder and Its Group Psychological Treatment |
title_short | Characterization of IGF-II Isoforms in Binge Eating Disorder and Its Group Psychological Treatment |
title_sort | characterization of igf-ii isoforms in binge eating disorder and its group psychological treatment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875431/ https://www.ncbi.nlm.nih.gov/pubmed/24386136 http://dx.doi.org/10.1371/journal.pone.0083019 |
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