Cargando…
Rheostats and Toggle Switches for Modulating Protein Function
The millions of protein sequences generated by genomics are expected to transform protein engineering and personalized medicine. To achieve these goals, tools for predicting outcomes of amino acid changes must be improved. Currently, advances are hampered by insufficient experimental data about nonc...
Autores principales: | Meinhardt, Sarah, Manley, Michael W., Parente, Daniel J., Swint-Kruse, Liskin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875437/ https://www.ncbi.nlm.nih.gov/pubmed/24386217 http://dx.doi.org/10.1371/journal.pone.0083502 |
Ejemplares similares
-
Substitutions at Nonconserved Rheostat Positions Modulate Function by Rewiring Long-Range, Dynamic Interactions
por: Campitelli, Paul, et al.
Publicado: (2020) -
Rheostat positions: A new classification of protein positions relevant to pharmacogenomics
por: Fenton, Aron W., et al.
Publicado: (2020) -
Functional tunability from a distance: Rheostat positions influence allosteric coupling between two distant binding sites
por: Wu, Tiffany, et al.
Publicado: (2019) -
Multiple Co-Evolutionary Networks Are Supported by the Common Tertiary Scaffold of the LacI/GalR Proteins
por: Parente, Daniel J., et al.
Publicado: (2013) -
The Spindle Assembly Checkpoint works like a rheostat not a toggle-switch
por: Collin, Philippe, et al.
Publicado: (2013)