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Exploration of Virtual Candidates for Human HMG-CoA Reductase Inhibitors Using Pharmacophore Modeling and Molecular Dynamics Simulations

3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is a rate-controlling enzyme in the mevalonate pathway which involved in biosynthesis of cholesterol and other isoprenoids. This enzyme catalyzes the conversion of HMG-CoA to mevalonate and is regarded as a drug target to treat hypercholesterole...

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Detalles Bibliográficos
Autores principales:	Son, Minky, Baek, Ayoung, Sakkiah, Sugunadevi, Park, Chanin, John, Shalini, Lee, Keun Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875450/ https://www.ncbi.nlm.nih.gov/pubmed/24386216 http://dx.doi.org/10.1371/journal.pone.0083496

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