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Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea

BACKGROUND: The impact of dialysis modality on survival is still somewhat controversial. Given possible differences in patients’ characteristics and the cause and rate of death in different countries, the issue needs to be evaluated in Korean cohorts. METHODS: A nationwide prospective observational...

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Autores principales: Choi, Ji-Young, Jang, Hye Min, Park, Jongha, Kim, Yon Su, Kang, Shin-Wook, Yang, Chul Woo, Kim, Nam-Ho, Cho, Jang-Hee, Park, Sun-Hee, Kim, Chan-Duck, Kim, Yong-Lim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875495/
https://www.ncbi.nlm.nih.gov/pubmed/24386357
http://dx.doi.org/10.1371/journal.pone.0084257
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author Choi, Ji-Young
Jang, Hye Min
Park, Jongha
Kim, Yon Su
Kang, Shin-Wook
Yang, Chul Woo
Kim, Nam-Ho
Cho, Jang-Hee
Park, Sun-Hee
Kim, Chan-Duck
Kim, Yong-Lim
author_facet Choi, Ji-Young
Jang, Hye Min
Park, Jongha
Kim, Yon Su
Kang, Shin-Wook
Yang, Chul Woo
Kim, Nam-Ho
Cho, Jang-Hee
Park, Sun-Hee
Kim, Chan-Duck
Kim, Yong-Lim
author_sort Choi, Ji-Young
collection PubMed
description BACKGROUND: The impact of dialysis modality on survival is still somewhat controversial. Given possible differences in patients’ characteristics and the cause and rate of death in different countries, the issue needs to be evaluated in Korean cohorts. METHODS: A nationwide prospective observational cohort study (NCT00931970) was performed to compare survival between peritoneal dialysis (PD) and hemodialysis (HD). A total of 1,060 end-stage renal disease patients in Korea who began dialysis between September 1, 2008 and June 30, 2011 were followed through December 31, 2011. RESULTS: The patients (PD, 30.6%; HD, 69.4%) were followed up for 16.3±7.9 months. PD patients were significantly younger, less likely to be diabetic, with lower body mass index, and larger urinary volume than HD patients. Infection was the most common cause of death. Multivariate Cox regression with the entire cohort revealed that PD tended to be associated with a lower risk of death compared to HD [hazard ratio (HR) 0.63, 95% confidence interval (CI) 0.36–1.08]. In propensity score matched pairs (n = 278 in each modality), cumulative survival probabilities for PD and HD patients were 96.9% and 94.1% at 12 months (P = 0.152) and 94.3% and 87.6% at 24 months (P = 0.022), respectively. Patients on PD had a 51% lower risk of death compared to those on HD (HR 0.49, 95% CI 0.25–0.97). CONCLUSIONS: PD exhibits superior survival to HD in the early period of dialysis, even after adjusting for differences in the patients’ characteristics between the two modalities. Notably, the most common cause of death was infection in this Korean cohort.
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spelling pubmed-38754952014-01-02 Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea Choi, Ji-Young Jang, Hye Min Park, Jongha Kim, Yon Su Kang, Shin-Wook Yang, Chul Woo Kim, Nam-Ho Cho, Jang-Hee Park, Sun-Hee Kim, Chan-Duck Kim, Yong-Lim PLoS One Research Article BACKGROUND: The impact of dialysis modality on survival is still somewhat controversial. Given possible differences in patients’ characteristics and the cause and rate of death in different countries, the issue needs to be evaluated in Korean cohorts. METHODS: A nationwide prospective observational cohort study (NCT00931970) was performed to compare survival between peritoneal dialysis (PD) and hemodialysis (HD). A total of 1,060 end-stage renal disease patients in Korea who began dialysis between September 1, 2008 and June 30, 2011 were followed through December 31, 2011. RESULTS: The patients (PD, 30.6%; HD, 69.4%) were followed up for 16.3±7.9 months. PD patients were significantly younger, less likely to be diabetic, with lower body mass index, and larger urinary volume than HD patients. Infection was the most common cause of death. Multivariate Cox regression with the entire cohort revealed that PD tended to be associated with a lower risk of death compared to HD [hazard ratio (HR) 0.63, 95% confidence interval (CI) 0.36–1.08]. In propensity score matched pairs (n = 278 in each modality), cumulative survival probabilities for PD and HD patients were 96.9% and 94.1% at 12 months (P = 0.152) and 94.3% and 87.6% at 24 months (P = 0.022), respectively. Patients on PD had a 51% lower risk of death compared to those on HD (HR 0.49, 95% CI 0.25–0.97). CONCLUSIONS: PD exhibits superior survival to HD in the early period of dialysis, even after adjusting for differences in the patients’ characteristics between the two modalities. Notably, the most common cause of death was infection in this Korean cohort. Public Library of Science 2013-12-30 /pmc/articles/PMC3875495/ /pubmed/24386357 http://dx.doi.org/10.1371/journal.pone.0084257 Text en © 2013 Choi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Choi, Ji-Young
Jang, Hye Min
Park, Jongha
Kim, Yon Su
Kang, Shin-Wook
Yang, Chul Woo
Kim, Nam-Ho
Cho, Jang-Hee
Park, Sun-Hee
Kim, Chan-Duck
Kim, Yong-Lim
Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea
title Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea
title_full Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea
title_fullStr Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea
title_full_unstemmed Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea
title_short Survival Advantage of Peritoneal Dialysis Relative to Hemodialysis in the Early Period of Incident Dialysis Patients: A Nationwide Prospective Propensity-Matched Study in Korea
title_sort survival advantage of peritoneal dialysis relative to hemodialysis in the early period of incident dialysis patients: a nationwide prospective propensity-matched study in korea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875495/
https://www.ncbi.nlm.nih.gov/pubmed/24386357
http://dx.doi.org/10.1371/journal.pone.0084257
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