Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China

Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1,...

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Autores principales: Zhang, Lei, Yan, Jie, Ojcius, David M., Lv, Huakun, Miao, Ziping, Chen, Yin, Zhang, Yanjun, Yan, Jvying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875553/
https://www.ncbi.nlm.nih.gov/pubmed/24386442
http://dx.doi.org/10.1371/journal.pone.0085023
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author Zhang, Lei
Yan, Jie
Ojcius, David M.
Lv, Huakun
Miao, Ziping
Chen, Yin
Zhang, Yanjun
Yan, Jvying
author_facet Zhang, Lei
Yan, Jie
Ojcius, David M.
Lv, Huakun
Miao, Ziping
Chen, Yin
Zhang, Yanjun
Yan, Jvying
author_sort Zhang, Lei
collection PubMed
description Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates from this study belonged to the human EV B (HEV B) family and were distributed in three clusters.
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spelling pubmed-38755532014-01-02 Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China Zhang, Lei Yan, Jie Ojcius, David M. Lv, Huakun Miao, Ziping Chen, Yin Zhang, Yanjun Yan, Jvying PLoS One Research Article Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates from this study belonged to the human EV B (HEV B) family and were distributed in three clusters. Public Library of Science 2013-12-30 /pmc/articles/PMC3875553/ /pubmed/24386442 http://dx.doi.org/10.1371/journal.pone.0085023 Text en © 2013 Yan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Lei
Yan, Jie
Ojcius, David M.
Lv, Huakun
Miao, Ziping
Chen, Yin
Zhang, Yanjun
Yan, Jvying
Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China
title Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China
title_full Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China
title_fullStr Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China
title_full_unstemmed Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China
title_short Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China
title_sort novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875553/
https://www.ncbi.nlm.nih.gov/pubmed/24386442
http://dx.doi.org/10.1371/journal.pone.0085023
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