A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy

The activation of NFκB in the tumor microenvironment is associated with inflammatory responses that promote disease progression. We have recently found that the activation of NFκB in the tumor also regulates T cell-mediated immune responses, hence actively participating in cancer immunosurveillance....

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Detalles Bibliográficos
Autores principales: Beg, Amer A, Khan, Tahira, Antonia, Scott J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875605/
https://www.ncbi.nlm.nih.gov/pubmed/24404421
http://dx.doi.org/10.4161/onci.25963
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author Beg, Amer A
Khan, Tahira
Antonia, Scott J
author_facet Beg, Amer A
Khan, Tahira
Antonia, Scott J
author_sort Beg, Amer A
collection PubMed
description The activation of NFκB in the tumor microenvironment is associated with inflammatory responses that promote disease progression. We have recently found that the activation of NFκB in the tumor also regulates T cell-mediated immune responses, hence actively participating in cancer immunosurveillance. These findings call for reassessment of the function of NFκB within neoplastic lesions and open novel perspectives for anticancer immunotherapy.
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spelling pubmed-38756052014-01-08 A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy Beg, Amer A Khan, Tahira Antonia, Scott J Oncoimmunology Author's View The activation of NFκB in the tumor microenvironment is associated with inflammatory responses that promote disease progression. We have recently found that the activation of NFκB in the tumor also regulates T cell-mediated immune responses, hence actively participating in cancer immunosurveillance. These findings call for reassessment of the function of NFκB within neoplastic lesions and open novel perspectives for anticancer immunotherapy. Landes Bioscience 2013-10-01 2013-08-02 /pmc/articles/PMC3875605/ /pubmed/24404421 http://dx.doi.org/10.4161/onci.25963 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Beg, Amer A
Khan, Tahira
Antonia, Scott J
A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy
title A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy
title_full A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy
title_fullStr A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy
title_full_unstemmed A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy
title_short A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy
title_sort new role for nfκb in immunosurveillance and its implications for cancer immunotherapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875605/
https://www.ncbi.nlm.nih.gov/pubmed/24404421
http://dx.doi.org/10.4161/onci.25963
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