HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

Deregulated expression of Hox genes such as HoxA9 is associated with development of myeloproliferative disorders and leukemia and indicates a poor prognosis. To investigate the molecular mechanisms by which HoxA9 promotes immortalization of hematopoietic cells, we generated growth factor dependent m...

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Detalles Bibliográficos
Autores principales: Brumatti, Gabriela, Salmanidis, Marika, Kok, Chung H, Bilardi, Rebecca A, Sandow, Jarrod J, Silke, Natasha, Mason, Kylie, Visser, Jolanda, Jabbour, Anissa M, Glaser, Stefan P, Okamoto, Toru, Bouillet, Philippe, D'Andrea, Richard J, Ekert, Paul G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875760/
https://www.ncbi.nlm.nih.gov/pubmed/24177192

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