Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX

Inhibitors of the molecular chaperone heat shock protein 90 (HSP90) are of considerable current interest as targeted cancer therapeutic agents because of the ability to destabilize multiple oncogenic client proteins. Despite their resulting pleiotropic effects on multiple oncogenic pathways and hall...

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Detalles Bibliográficos
Autores principales: Powers, Marissa V, Valenti, Melanie, Miranda, Susana, Maloney, Alison, Eccles, Suzanne A., Thomas, George, Clarke, Paul A, Workman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875762/
https://www.ncbi.nlm.nih.gov/pubmed/24185264

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