Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

DNA variants (SNPs) that predispose to common traits often localize within noncoding regulatory elements such as enhancers. Moreover, loci identified by genome-wide association studies (GWAS) often contain multiple SNPs in linkage disequilibrium (LD), any of which may be causal. Thus, determining th...

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Detalles Bibliográficos
Autores principales: Corradin, Olivia, Saiakhova, Alina, Akhtar-Zaidi, Batool, Myeroff, Lois, Willis, Joseph, Cowper-Sal·lari, Richard, Lupien, Mathieu, Markowitz, Sanford, Scacheri, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875850/
https://www.ncbi.nlm.nih.gov/pubmed/24196873
http://dx.doi.org/10.1101/gr.164079.113

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