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Loss of the AE3 Cl(−)/HCO(−)(3) exchanger in mice affects rate-dependent inotropy and stress-related AKT signaling in heart

Cl(−)/HCO(−)(3) exchangers are expressed abundantly in cardiac muscle, suggesting that HCO(−)(3) extrusion serves an important function in heart. Mice lacking Anion Exchanger Isoform 3 (AE3), a major cardiac Cl(−)/HCO(−)(3) exchanger, appear healthy, but loss of AE3 causes decompensation in a hypert...

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Detalles Bibliográficos
Autores principales:	Prasad, Vikram, Lorenz, John N., Lasko, Valerie M., Nieman, Michelle L., Al Moamen, Nabeel J., Shull, Gary E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875869/ https://www.ncbi.nlm.nih.gov/pubmed/24427143 http://dx.doi.org/10.3389/fphys.2013.00399

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