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Neuroenhancement with Vitamin B12—Underestimated Neurological Significance
Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development. A Vitamin B12 deficiency expresses itself by...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875920/ https://www.ncbi.nlm.nih.gov/pubmed/24352086 http://dx.doi.org/10.3390/nu5125031 |
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author | Gröber, Uwe Kisters, Klaus Schmidt, Joachim |
author_facet | Gröber, Uwe Kisters, Klaus Schmidt, Joachim |
author_sort | Gröber, Uwe |
collection | PubMed |
description | Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development. A Vitamin B12 deficiency expresses itself by a wide variety of neurological manifestations such as paraesthesias, skin numbness, coordination disorders and reduced nerve conduction velocity. In elderly people, a latent Vitamin B12 deficiency can be associated with a progressive brain atrophy. Moderately elevated concentrations of homocysteine (>10 µmol/L) have been associated with an increased risk of dementia, notably Alzheimer’s disease, in many cross-sectional and prospective studies. Raised plasma concentrations of homocysteine is also associated with both regional and whole brain atrophy, not only in Alzheimer’s disease but also in healthy elderly people. Clinician awareness should be raised to accurately diagnose and treat early Vitamin B12 deficiency to prevent irreversible structural brain damage. |
format | Online Article Text |
id | pubmed-3875920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38759202013-12-31 Neuroenhancement with Vitamin B12—Underestimated Neurological Significance Gröber, Uwe Kisters, Klaus Schmidt, Joachim Nutrients Review Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development. A Vitamin B12 deficiency expresses itself by a wide variety of neurological manifestations such as paraesthesias, skin numbness, coordination disorders and reduced nerve conduction velocity. In elderly people, a latent Vitamin B12 deficiency can be associated with a progressive brain atrophy. Moderately elevated concentrations of homocysteine (>10 µmol/L) have been associated with an increased risk of dementia, notably Alzheimer’s disease, in many cross-sectional and prospective studies. Raised plasma concentrations of homocysteine is also associated with both regional and whole brain atrophy, not only in Alzheimer’s disease but also in healthy elderly people. Clinician awareness should be raised to accurately diagnose and treat early Vitamin B12 deficiency to prevent irreversible structural brain damage. MDPI 2013-12-12 /pmc/articles/PMC3875920/ /pubmed/24352086 http://dx.doi.org/10.3390/nu5125031 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Gröber, Uwe Kisters, Klaus Schmidt, Joachim Neuroenhancement with Vitamin B12—Underestimated Neurological Significance |
title | Neuroenhancement with Vitamin B12—Underestimated Neurological Significance |
title_full | Neuroenhancement with Vitamin B12—Underestimated Neurological Significance |
title_fullStr | Neuroenhancement with Vitamin B12—Underestimated Neurological Significance |
title_full_unstemmed | Neuroenhancement with Vitamin B12—Underestimated Neurological Significance |
title_short | Neuroenhancement with Vitamin B12—Underestimated Neurological Significance |
title_sort | neuroenhancement with vitamin b12—underestimated neurological significance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875920/ https://www.ncbi.nlm.nih.gov/pubmed/24352086 http://dx.doi.org/10.3390/nu5125031 |
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