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Neuroenhancement with Vitamin B12—Underestimated Neurological Significance

Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development. A Vitamin B12 deficiency expresses itself by...

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Autores principales: Gröber, Uwe, Kisters, Klaus, Schmidt, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875920/
https://www.ncbi.nlm.nih.gov/pubmed/24352086
http://dx.doi.org/10.3390/nu5125031
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author Gröber, Uwe
Kisters, Klaus
Schmidt, Joachim
author_facet Gröber, Uwe
Kisters, Klaus
Schmidt, Joachim
author_sort Gröber, Uwe
collection PubMed
description Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development. A Vitamin B12 deficiency expresses itself by a wide variety of neurological manifestations such as paraesthesias, skin numbness, coordination disorders and reduced nerve conduction velocity. In elderly people, a latent Vitamin B12 deficiency can be associated with a progressive brain atrophy. Moderately elevated concentrations of homocysteine (>10 µmol/L) have been associated with an increased risk of dementia, notably Alzheimer’s disease, in many cross-sectional and prospective studies. Raised plasma concentrations of homocysteine is also associated with both regional and whole brain atrophy, not only in Alzheimer’s disease but also in healthy elderly people. Clinician awareness should be raised to accurately diagnose and treat early Vitamin B12 deficiency to prevent irreversible structural brain damage.
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spelling pubmed-38759202013-12-31 Neuroenhancement with Vitamin B12—Underestimated Neurological Significance Gröber, Uwe Kisters, Klaus Schmidt, Joachim Nutrients Review Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development. A Vitamin B12 deficiency expresses itself by a wide variety of neurological manifestations such as paraesthesias, skin numbness, coordination disorders and reduced nerve conduction velocity. In elderly people, a latent Vitamin B12 deficiency can be associated with a progressive brain atrophy. Moderately elevated concentrations of homocysteine (>10 µmol/L) have been associated with an increased risk of dementia, notably Alzheimer’s disease, in many cross-sectional and prospective studies. Raised plasma concentrations of homocysteine is also associated with both regional and whole brain atrophy, not only in Alzheimer’s disease but also in healthy elderly people. Clinician awareness should be raised to accurately diagnose and treat early Vitamin B12 deficiency to prevent irreversible structural brain damage. MDPI 2013-12-12 /pmc/articles/PMC3875920/ /pubmed/24352086 http://dx.doi.org/10.3390/nu5125031 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Gröber, Uwe
Kisters, Klaus
Schmidt, Joachim
Neuroenhancement with Vitamin B12—Underestimated Neurological Significance
title Neuroenhancement with Vitamin B12—Underestimated Neurological Significance
title_full Neuroenhancement with Vitamin B12—Underestimated Neurological Significance
title_fullStr Neuroenhancement with Vitamin B12—Underestimated Neurological Significance
title_full_unstemmed Neuroenhancement with Vitamin B12—Underestimated Neurological Significance
title_short Neuroenhancement with Vitamin B12—Underestimated Neurological Significance
title_sort neuroenhancement with vitamin b12—underestimated neurological significance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875920/
https://www.ncbi.nlm.nih.gov/pubmed/24352086
http://dx.doi.org/10.3390/nu5125031
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