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Blastic plasmacytoid dendritic cell neoplasm
Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Dermatologia
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876014/ https://www.ncbi.nlm.nih.gov/pubmed/24346907 http://dx.doi.org/10.1590/abd1806-4841.20132388 |
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author | Lencastre, André Cabete, Joana João, Alexandre Farinha, Pedro Ferreira, Gilda Lestre, Sara |
author_facet | Lencastre, André Cabete, Joana João, Alexandre Farinha, Pedro Ferreira, Gilda Lestre, Sara |
author_sort | Lencastre, André |
collection | PubMed |
description | Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise. |
format | Online Article Text |
id | pubmed-3876014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-38760142014-01-08 Blastic plasmacytoid dendritic cell neoplasm Lencastre, André Cabete, Joana João, Alexandre Farinha, Pedro Ferreira, Gilda Lestre, Sara An Bras Dermatol Case Report Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise. Sociedade Brasileira de Dermatologia 2013 /pmc/articles/PMC3876014/ /pubmed/24346907 http://dx.doi.org/10.1590/abd1806-4841.20132388 Text en ©2013 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Lencastre, André Cabete, Joana João, Alexandre Farinha, Pedro Ferreira, Gilda Lestre, Sara Blastic plasmacytoid dendritic cell neoplasm |
title | Blastic plasmacytoid dendritic cell neoplasm
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title_full | Blastic plasmacytoid dendritic cell neoplasm
|
title_fullStr | Blastic plasmacytoid dendritic cell neoplasm
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title_full_unstemmed | Blastic plasmacytoid dendritic cell neoplasm
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title_short | Blastic plasmacytoid dendritic cell neoplasm
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title_sort | blastic plasmacytoid dendritic cell neoplasm |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876014/ https://www.ncbi.nlm.nih.gov/pubmed/24346907 http://dx.doi.org/10.1590/abd1806-4841.20132388 |
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