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Blastic plasmacytoid dendritic cell neoplasm

Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, a...

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Autores principales: Lencastre, André, Cabete, Joana, João, Alexandre, Farinha, Pedro, Ferreira, Gilda, Lestre, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876014/
https://www.ncbi.nlm.nih.gov/pubmed/24346907
http://dx.doi.org/10.1590/abd1806-4841.20132388
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author Lencastre, André
Cabete, Joana
João, Alexandre
Farinha, Pedro
Ferreira, Gilda
Lestre, Sara
author_facet Lencastre, André
Cabete, Joana
João, Alexandre
Farinha, Pedro
Ferreira, Gilda
Lestre, Sara
author_sort Lencastre, André
collection PubMed
description Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise.
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spelling pubmed-38760142014-01-08 Blastic plasmacytoid dendritic cell neoplasm Lencastre, André Cabete, Joana João, Alexandre Farinha, Pedro Ferreira, Gilda Lestre, Sara An Bras Dermatol Case Report Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise. Sociedade Brasileira de Dermatologia 2013 /pmc/articles/PMC3876014/ /pubmed/24346907 http://dx.doi.org/10.1590/abd1806-4841.20132388 Text en ©2013 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lencastre, André
Cabete, Joana
João, Alexandre
Farinha, Pedro
Ferreira, Gilda
Lestre, Sara
Blastic plasmacytoid dendritic cell neoplasm
title Blastic plasmacytoid dendritic cell neoplasm
title_full Blastic plasmacytoid dendritic cell neoplasm
title_fullStr Blastic plasmacytoid dendritic cell neoplasm
title_full_unstemmed Blastic plasmacytoid dendritic cell neoplasm
title_short Blastic plasmacytoid dendritic cell neoplasm
title_sort blastic plasmacytoid dendritic cell neoplasm
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876014/
https://www.ncbi.nlm.nih.gov/pubmed/24346907
http://dx.doi.org/10.1590/abd1806-4841.20132388
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