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Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model

The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by...

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Detalles Bibliográficos
Autores principales: Šaban, Nina, Stepanić, Višnja, Vučinić, Srđan, Horvatić, Anita, Cindrić, Mario, Perković, Ivana, Zorc, Branka, Oršolić, Nada, Mintas, Mladen, Pavelić, Krešimir, Pavelić, Sandra Kraljević
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876069/
https://www.ncbi.nlm.nih.gov/pubmed/24304540
http://dx.doi.org/10.3390/ijms141223654
Descripción
Sumario:The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.