Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model

The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by...

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Detalles Bibliográficos
Autores principales: Šaban, Nina, Stepanić, Višnja, Vučinić, Srđan, Horvatić, Anita, Cindrić, Mario, Perković, Ivana, Zorc, Branka, Oršolić, Nada, Mintas, Mladen, Pavelić, Krešimir, Pavelić, Sandra Kraljević
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876069/
https://www.ncbi.nlm.nih.gov/pubmed/24304540
http://dx.doi.org/10.3390/ijms141223654
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author Šaban, Nina
Stepanić, Višnja
Vučinić, Srđan
Horvatić, Anita
Cindrić, Mario
Perković, Ivana
Zorc, Branka
Oršolić, Nada
Mintas, Mladen
Pavelić, Krešimir
Pavelić, Sandra Kraljević
author_facet Šaban, Nina
Stepanić, Višnja
Vučinić, Srđan
Horvatić, Anita
Cindrić, Mario
Perković, Ivana
Zorc, Branka
Oršolić, Nada
Mintas, Mladen
Pavelić, Krešimir
Pavelić, Sandra Kraljević
author_sort Šaban, Nina
collection PubMed
description The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.
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spelling pubmed-38760692013-12-31 Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model Šaban, Nina Stepanić, Višnja Vučinić, Srđan Horvatić, Anita Cindrić, Mario Perković, Ivana Zorc, Branka Oršolić, Nada Mintas, Mladen Pavelić, Krešimir Pavelić, Sandra Kraljević Int J Mol Sci Article The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect. Molecular Diversity Preservation International (MDPI) 2013-12-04 /pmc/articles/PMC3876069/ /pubmed/24304540 http://dx.doi.org/10.3390/ijms141223654 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Šaban, Nina
Stepanić, Višnja
Vučinić, Srđan
Horvatić, Anita
Cindrić, Mario
Perković, Ivana
Zorc, Branka
Oršolić, Nada
Mintas, Mladen
Pavelić, Krešimir
Pavelić, Sandra Kraljević
Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model
title Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model
title_full Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model
title_fullStr Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model
title_full_unstemmed Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model
title_short Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model
title_sort antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876069/
https://www.ncbi.nlm.nih.gov/pubmed/24304540
http://dx.doi.org/10.3390/ijms141223654
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