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Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice

This study examined the effects of xylitol on mouse intestinal microbiota and urinary isoflavonoids. Xylitol is classified as a sugar alcohol and used as a food additive. The intestinal microbiota seems to play an important role in isoflavone metabolism. Xylitol feeding appears to affect the gut mic...

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Autores principales: Tamura, Motoi, Hoshi, Chigusa, Hori, Sachiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876090/
https://www.ncbi.nlm.nih.gov/pubmed/24336061
http://dx.doi.org/10.3390/ijms141223993
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author Tamura, Motoi
Hoshi, Chigusa
Hori, Sachiko
author_facet Tamura, Motoi
Hoshi, Chigusa
Hori, Sachiko
author_sort Tamura, Motoi
collection PubMed
description This study examined the effects of xylitol on mouse intestinal microbiota and urinary isoflavonoids. Xylitol is classified as a sugar alcohol and used as a food additive. The intestinal microbiota seems to play an important role in isoflavone metabolism. Xylitol feeding appears to affect the gut microbiota. We hypothesized that dietary xylitol changes intestinal microbiota and, therefore, the metabolism of isoflavonoids in mice. Male mice were randomly divided into two groups: those fed a 0.05% daidzein with 5% xylitol diet (XD group) and those fed a 0.05% daidzein-containing control diet (CD group) for 28 days. Plasma total cholesterol concentrations were significantly lower in the XD group than in the CD group (p < 0.05). Urinary amounts of equol were significantly higher in the XD group than in the CD group (p < 0.05). The fecal lipid contents (% dry weight) were significantly greater in the XD group than in the CD group (p < 0.01). The cecal microbiota differed between the two dietary groups. The occupation ratios of Bacteroides were significantly greater in the CD than in the XD group (p < 0.05). This study suggests that xylitol has the potential to affect the metabolism of daidzein by altering the metabolic activity of the intestinal microbiota and/or gut environment. Given that equol affects bone health, dietary xylitol plus isoflavonoids may exert a favorable effect on bone health.
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spelling pubmed-38760902013-12-31 Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice Tamura, Motoi Hoshi, Chigusa Hori, Sachiko Int J Mol Sci Article This study examined the effects of xylitol on mouse intestinal microbiota and urinary isoflavonoids. Xylitol is classified as a sugar alcohol and used as a food additive. The intestinal microbiota seems to play an important role in isoflavone metabolism. Xylitol feeding appears to affect the gut microbiota. We hypothesized that dietary xylitol changes intestinal microbiota and, therefore, the metabolism of isoflavonoids in mice. Male mice were randomly divided into two groups: those fed a 0.05% daidzein with 5% xylitol diet (XD group) and those fed a 0.05% daidzein-containing control diet (CD group) for 28 days. Plasma total cholesterol concentrations were significantly lower in the XD group than in the CD group (p < 0.05). Urinary amounts of equol were significantly higher in the XD group than in the CD group (p < 0.05). The fecal lipid contents (% dry weight) were significantly greater in the XD group than in the CD group (p < 0.01). The cecal microbiota differed between the two dietary groups. The occupation ratios of Bacteroides were significantly greater in the CD than in the XD group (p < 0.05). This study suggests that xylitol has the potential to affect the metabolism of daidzein by altering the metabolic activity of the intestinal microbiota and/or gut environment. Given that equol affects bone health, dietary xylitol plus isoflavonoids may exert a favorable effect on bone health. Molecular Diversity Preservation International (MDPI) 2013-12-10 /pmc/articles/PMC3876090/ /pubmed/24336061 http://dx.doi.org/10.3390/ijms141223993 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tamura, Motoi
Hoshi, Chigusa
Hori, Sachiko
Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice
title Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice
title_full Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice
title_fullStr Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice
title_full_unstemmed Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice
title_short Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice
title_sort xylitol affects the intestinal microbiota and metabolism of daidzein in adult male mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876090/
https://www.ncbi.nlm.nih.gov/pubmed/24336061
http://dx.doi.org/10.3390/ijms141223993
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AT horisachiko xylitolaffectstheintestinalmicrobiotaandmetabolismofdaidzeininadultmalemice