Cargando…

The Antidiabetic Drug Metformin Inhibits the Proliferation of Bladder Cancer Cells in Vitro and in Vivo

Recent studies suggest that metformin, a widely used antidiabetic agent, may reduce cancer risk and improve prognosis of certain malignancies. However, the mechanisms for the anti-cancer effects of metformin remain uncertain. In this study, we investigated the effects of metformin on human bladder c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Tao, Guo, Peng, Zhang, Yinan, Xiong, Hui, Yu, Xiao, Xu, Shan, Wang, Xinyang, He, Dalin, Jin, Xunbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876131/ https://www.ncbi.nlm.nih.gov/pubmed/24351837 http://dx.doi.org/10.3390/ijms141224603

Ejemplares similares

Metformin inhibited esophageal squamous cell carcinoma proliferation in vitro and in vivo and enhanced the anti-cancer effect of cisplatin
por: Wang, Feng, et al.
Publicado: (2017)

Evodiamine Induces Apoptosis and Enhances TRAIL-Induced Apoptosis in Human Bladder Cancer Cells through mTOR/S6K1-Mediated Downregulation of Mcl-1
por: Zhang, Tao, et al.
Publicado: (2014)

Antidiabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1
por: Chen, Yiyan, et al.
Publicado: (2022)

Spatiotemporal Expression of SHH/GLI Signaling in Human Fetal Bladder Development
por: Zhang, Haibao, et al.
Publicado: (2021)

Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo
por: Tang, Jian-Cai, et al.
Publicado: (2017)

Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence
por: Vlavcheski, Filip, et al.
Publicado: (2019)

In Vitro and In Vivo Antidiabetic Potential of Monoterpenoids: An Update
por: Al Kury, Lina T., et al.
Publicado: (2021)

Regulatory Effects of Metformin, an Antidiabetic Biguanide Drug, on the Metabolism of Primary Rat Adipocytes
por: Szkudelski, Tomasz, et al.
Publicado: (2022)

Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo
por: Yang, Xiong, et al.
Publicado: (2019)

Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo
por: Mussin, Nadiar, et al.
Publicado: (2017)

The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo
por: Gámez, Beatriz, et al.
Publicado: (2021)

In Vitro and In Vivo Evaluation of Antidiabetic Properties and Mechanisms of Ficus tikoua Bur.
por: Wang, Hanlei, et al.
Publicado: (2022)

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration
por: Brown, Emily E., et al.
Publicado: (2019)

AB064. Internet plus health care: review of the policies, consulting reports and advise for the urologists
por: Zhang, Yinan, et al.
Publicado: (2015)

Downregulation of BLM RecQ helicase inhibits proliferation, promotes the apoptosis and enhances the sensitivity of bladder cancer cells to cisplatin
por: Feng, Sujuan, et al.
Publicado: (2022)

Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches
por: Ashraf, Ghulam Md., et al.
Publicado: (2022)

Uncovering antiobesity-related hypertension targets and mechanisms of metformin, an antidiabetic medication
por: Yang, Lu, et al.
Publicado: (2021)

Aquaporin 1 knockdown inhibits triple-negative breast cancer cell proliferation and invasion in vitro and in vivo
por: Ji, Yinan, et al.
Publicado: (2021)

Phenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo
por: Wang, Yanmin, et al.
Publicado: (2018)

MT-12 inhibits the proliferation of bladder cells in vitro and in vivo by enhancing autophagy through mitochondrial dysfunction
por: Chen, Yan, et al.
Publicado: (2022)

BET inhibitor JQ1 suppresses cell proliferation via inducing autophagy and activating LKB1/AMPK in bladder cancer cells
por: Li, Feng, et al.
Publicado: (2019)

Antidiabetic Activity of Hydromethanolic Extract of Crude Dorstenia barnimiana Root: Validation of In Vitro and In Vivo Antidiabetic and Antidyslipidemic Activity
por: Sisay, Woretaw, et al.
Publicado: (2022)

KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo
por: Tian, Da-Wei, et al.
Publicado: (2019)

Metformin Prevents Renal Stone Formation through an Antioxidant Mechanism In Vitro and In Vivo
por: Yang, Xiong, et al.
Publicado: (2016)

Development and validation of a new analytical HPLC method for simultaneous determination of the antidiabetic drugs, metformin and gliclazide
por: Gedawy, Ahmed, et al.
Publicado: (2018)

A Methylotrophic Bacterium Growing with the Antidiabetic Drug Metformin as Its Sole Carbon, Nitrogen and Energy Source
por: Chaignaud, Pauline, et al.
Publicado: (2022)

The Antidiabetic Agent Metformin Inhibits IL-23 Production in Murine Bone-Marrow-Derived Dendritic Cells
por: Matsuda-Taniguchi, Tomoyo, et al.
Publicado: (2021)

CRISPR-ON-Mediated KLF4 overexpression inhibits the proliferation, migration and invasion of urothelial bladder cancer in vitro and in vivo
por: Xu, Xin, et al.
Publicado: (2017)

In vitro and in vivo Antidiabetic Properties of Phenolic Antioxidants From Sedum adenotrichum
por: Naz, Dil, et al.
Publicado: (2019)

Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo
por: WU, CUNZAO, et al.
Publicado: (2015)

Effects of metformin on retinoblastoma growth in vitro and in vivo
por: BRODOWSKA, KATARZYNA, et al.
Publicado: (2014)

Comparison of Oral Antidiabetic Drugs as Add-On Treatments in Patients with Type 2 Diabetes Uncontrolled on Metformin: A Network Meta-Analysis
por: Qian, Dan, et al.
Publicado: (2018)

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo
por: ZHANG, XIANQING, et al.
Publicado: (2014)

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo
por: Zhang, Xianqing, et al.
Publicado: (2018)

Glimepiride-Loaded Nanoemulgel; Development, In Vitro Characterization, Ex Vivo Permeation and In Vivo Antidiabetic Evaluation
por: Razzaq, Fizza Abdul, et al.
Publicado: (2021)

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia: A nested case-control analysis
por: Bodmer, Michael, et al.
Publicado: (2008)

Antidiabetic Drug Metformin Protects Neuronal Cells against Quinolinic Acid-Induced Excitotoxicity by Decreasing Intracellular Calcium
por: Jang, Sujeong, et al.
Publicado: (2018)

Does the antidiabetic drug metformin affect embryo development and the health of brown trout (Salmo trutta f. fario)?
por: Jacob, Stefanie, et al.
Publicado: (2018)

Effects of guanylurea, the transformation product of the antidiabetic drug metformin, on the health of brown trout (Salmo trutta f. fario)
por: Jacob, Stefanie, et al.
Publicado: (2019)

The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA
por: Yao, Luxia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_63vtm0joaoc75ppreo8d2vg0em