JAK-STAT and intestinal mucosal immunology

The intestinal mucosal immune system is challenged with bacteria, viruses, and parasites, in addition to food and environmental antigens, that require dynamic immune responsiveness for homeostasis. One central signaling pathway is JAK-STAT, which regulates the adaptive and innate immune arms of muco...

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Detalles Bibliográficos
Autores principales: Heneghan, Aaron F, Pierre, Joseph F, Kudsk, Kenneth A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876429/
https://www.ncbi.nlm.nih.gov/pubmed/24416649
http://dx.doi.org/10.4161/jkst.25530
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author Heneghan, Aaron F
Pierre, Joseph F
Kudsk, Kenneth A
author_facet Heneghan, Aaron F
Pierre, Joseph F
Kudsk, Kenneth A
author_sort Heneghan, Aaron F
collection PubMed
description The intestinal mucosal immune system is challenged with bacteria, viruses, and parasites, in addition to food and environmental antigens, that require dynamic immune responsiveness for homeostasis. One central signaling pathway is JAK-STAT, which regulates the adaptive and innate immune arms of mucosal immunity as well as epithelial repair and regeneration. Adaptive immunity includes lymphocyte mediated secretion of specific antibodies, while innate immune respones include secretion of non-antigen specific compounds. This review examines effects of specialized nutrition support on JAK-STAT in innate immune function and in lymphocyte modulation and epithelial antibody transport in gut-associated lymphoid tissue.
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spelling pubmed-38764292014-01-10 JAK-STAT and intestinal mucosal immunology Heneghan, Aaron F Pierre, Joseph F Kudsk, Kenneth A JAKSTAT Review The intestinal mucosal immune system is challenged with bacteria, viruses, and parasites, in addition to food and environmental antigens, that require dynamic immune responsiveness for homeostasis. One central signaling pathway is JAK-STAT, which regulates the adaptive and innate immune arms of mucosal immunity as well as epithelial repair and regeneration. Adaptive immunity includes lymphocyte mediated secretion of specific antibodies, while innate immune respones include secretion of non-antigen specific compounds. This review examines effects of specialized nutrition support on JAK-STAT in innate immune function and in lymphocyte modulation and epithelial antibody transport in gut-associated lymphoid tissue. Landes Bioscience 2013-10-01 2013-06-26 /pmc/articles/PMC3876429/ /pubmed/24416649 http://dx.doi.org/10.4161/jkst.25530 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Heneghan, Aaron F
Pierre, Joseph F
Kudsk, Kenneth A
JAK-STAT and intestinal mucosal immunology
title JAK-STAT and intestinal mucosal immunology
title_full JAK-STAT and intestinal mucosal immunology
title_fullStr JAK-STAT and intestinal mucosal immunology
title_full_unstemmed JAK-STAT and intestinal mucosal immunology
title_short JAK-STAT and intestinal mucosal immunology
title_sort jak-stat and intestinal mucosal immunology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876429/
https://www.ncbi.nlm.nih.gov/pubmed/24416649
http://dx.doi.org/10.4161/jkst.25530
work_keys_str_mv AT heneghanaaronf jakstatandintestinalmucosalimmunology
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