Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells

The retinal pigmented epithelium (RPE) is a monolayer of specialized epithelial cells located between the photoreceptors of the retina and the choroidal blood supply. The RPE is essential for maintaining retinal health and vision. Recent findings identified STAT3 as a newly recognized regulator of R...

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Detalles Bibliográficos
Autores principales: Patel, Amit K, Syeda, Sarah, Hackam, Abigail S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876436/
https://www.ncbi.nlm.nih.gov/pubmed/24416648
http://dx.doi.org/10.4161/jkst.25434
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author Patel, Amit K
Syeda, Sarah
Hackam, Abigail S
author_facet Patel, Amit K
Syeda, Sarah
Hackam, Abigail S
author_sort Patel, Amit K
collection PubMed
description The retinal pigmented epithelium (RPE) is a monolayer of specialized epithelial cells located between the photoreceptors of the retina and the choroidal blood supply. The RPE is essential for maintaining retinal health and vision. Recent findings identified STAT3 as a newly recognized regulator of RPE survival, inflammatory response, visual cycle maintenance, and cytokine release. Additionally, STAT3 is implicated in retinal diseases that affect the RPE, including the common blinding disease age-related macular degeneration. Determining how STAT3 influences RPE functions ultimately may lead to novel therapeutics for retinal disease. In this review, we summarize the roles of JAK-STAT3 signaling in the RPE, and its potential contribution to retinal degenerations.
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spelling pubmed-38764362014-01-10 Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells Patel, Amit K Syeda, Sarah Hackam, Abigail S JAKSTAT Review The retinal pigmented epithelium (RPE) is a monolayer of specialized epithelial cells located between the photoreceptors of the retina and the choroidal blood supply. The RPE is essential for maintaining retinal health and vision. Recent findings identified STAT3 as a newly recognized regulator of RPE survival, inflammatory response, visual cycle maintenance, and cytokine release. Additionally, STAT3 is implicated in retinal diseases that affect the RPE, including the common blinding disease age-related macular degeneration. Determining how STAT3 influences RPE functions ultimately may lead to novel therapeutics for retinal disease. In this review, we summarize the roles of JAK-STAT3 signaling in the RPE, and its potential contribution to retinal degenerations. Landes Bioscience 2013-10-01 2013-06-17 /pmc/articles/PMC3876436/ /pubmed/24416648 http://dx.doi.org/10.4161/jkst.25434 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Patel, Amit K
Syeda, Sarah
Hackam, Abigail S
Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells
title Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells
title_full Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells
title_fullStr Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells
title_full_unstemmed Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells
title_short Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells
title_sort signal transducer and activator of transcription 3 (stat3) signaling in retinal pigment epithelium cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876436/
https://www.ncbi.nlm.nih.gov/pubmed/24416648
http://dx.doi.org/10.4161/jkst.25434
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