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Prevention of Acoustic Trauma-Induced Hearing Loss by N-acetylcysteine Administration in Rabbits
BACKGROUND: Acoustic trauma is an injury to the hearing mechanisms in the inner ear due to excessive noise. This injury is the most prevalent cause of sensorineural hearing loss in humans, especially from occupational exposure. Previous studies have shown the essential role of free radical formation...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876495/ https://www.ncbi.nlm.nih.gov/pubmed/24396768 http://dx.doi.org/10.5812/atr.7839 |
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author | Motalebi Kashani, Masoud Saberi, Hamidreza Hannani, Mitra |
author_facet | Motalebi Kashani, Masoud Saberi, Hamidreza Hannani, Mitra |
author_sort | Motalebi Kashani, Masoud |
collection | PubMed |
description | BACKGROUND: Acoustic trauma is an injury to the hearing mechanisms in the inner ear due to excessive noise. This injury is the most prevalent cause of sensorineural hearing loss in humans, especially from occupational exposure. Previous studies have shown the essential role of free radical formation in the inner ear hearing loss caused by acoustic trauma. OBJECTIVES: This study was performed to determine the effect of N-acetylcysteine (NAC) administration for reducing acute acoustic trauma in rabbits. MATERIALS AND METHODS: Twenty four rabbits were assigned to four groups including: control, noise plus saline, noise plus NAC administration (325 mg/kg body weight by intraperitoneal injection (IP), three days before exposure to noise and three days after noise exposure), and NAC alone. Auditory brain stem response (ABR) threshold was measured before exposure and one hour and 14 days after exposure. RESULTS: The saline plus noise group had on average a 49 decibel (dB) temporary threshold shift (TTS) and 23.9 dB permanent threshold shift (PTS) at the studied frequencies, while rabbits in the NAC administration plus noise group had a 31.5 dB TTS and 10.7 dB PTS averaged across the frequencies. CONCLUSIONS: Administration of NAC can provide appropriate protection against acoustic trauma-induced hearing loss in rabbits at all studied frequencies. |
format | Online Article Text |
id | pubmed-3876495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-38764952014-01-06 Prevention of Acoustic Trauma-Induced Hearing Loss by N-acetylcysteine Administration in Rabbits Motalebi Kashani, Masoud Saberi, Hamidreza Hannani, Mitra Arch Trauma Res Research Article BACKGROUND: Acoustic trauma is an injury to the hearing mechanisms in the inner ear due to excessive noise. This injury is the most prevalent cause of sensorineural hearing loss in humans, especially from occupational exposure. Previous studies have shown the essential role of free radical formation in the inner ear hearing loss caused by acoustic trauma. OBJECTIVES: This study was performed to determine the effect of N-acetylcysteine (NAC) administration for reducing acute acoustic trauma in rabbits. MATERIALS AND METHODS: Twenty four rabbits were assigned to four groups including: control, noise plus saline, noise plus NAC administration (325 mg/kg body weight by intraperitoneal injection (IP), three days before exposure to noise and three days after noise exposure), and NAC alone. Auditory brain stem response (ABR) threshold was measured before exposure and one hour and 14 days after exposure. RESULTS: The saline plus noise group had on average a 49 decibel (dB) temporary threshold shift (TTS) and 23.9 dB permanent threshold shift (PTS) at the studied frequencies, while rabbits in the NAC administration plus noise group had a 31.5 dB TTS and 10.7 dB PTS averaged across the frequencies. CONCLUSIONS: Administration of NAC can provide appropriate protection against acoustic trauma-induced hearing loss in rabbits at all studied frequencies. Kowsar 2013-02-01 2013 /pmc/articles/PMC3876495/ /pubmed/24396768 http://dx.doi.org/10.5812/atr.7839 Text en Copyright © 2013, Kashan University of Medical Sciences http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Motalebi Kashani, Masoud Saberi, Hamidreza Hannani, Mitra Prevention of Acoustic Trauma-Induced Hearing Loss by N-acetylcysteine Administration in Rabbits |
title | Prevention of Acoustic Trauma-Induced Hearing Loss by N-acetylcysteine Administration in Rabbits |
title_full | Prevention of Acoustic Trauma-Induced Hearing Loss by N-acetylcysteine Administration in Rabbits |
title_fullStr | Prevention of Acoustic Trauma-Induced Hearing Loss by N-acetylcysteine Administration in Rabbits |
title_full_unstemmed | Prevention of Acoustic Trauma-Induced Hearing Loss by N-acetylcysteine Administration in Rabbits |
title_short | Prevention of Acoustic Trauma-Induced Hearing Loss by N-acetylcysteine Administration in Rabbits |
title_sort | prevention of acoustic trauma-induced hearing loss by n-acetylcysteine administration in rabbits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876495/ https://www.ncbi.nlm.nih.gov/pubmed/24396768 http://dx.doi.org/10.5812/atr.7839 |
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