Fluoride levels and osteosarcoma

CONTEXT: Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma. AIMS: The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water. SETTINGS AND DESIGN: The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls). MATERIALS AND METHODS: Serum and drinking water fluoride levels were estimated by ion selective electrode. STATISTICAL ANALYSIS USED: The data were computed as mean ± SD and Student’s t test was applied. RESULTS: Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P > 0.05, P > 0.001, respectively). CONCLUSIONS: These results suggest a link between fluoride exposure and osteosarcoma.