RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist

Increased synthesis of Apolipoprotein A-I (ApoA-I) and HDL is believed to provide a new approach to treating atherosclerosis through the stimulation of reverse cholesterol transport. RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in monkeys and humans, which results...

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Detalles Bibliográficos
Autores principales: McLure, Kevin G., Gesner, Emily M., Tsujikawa, Laura, Kharenko, Olesya A., Attwell, Sarah, Campeau, Eric, Wasiak, Sylwia, Stein, Adam, White, Andre, Fontano, Eric, Suto, Robert K., Wong, Norman C. W., Wagner, Gregory S., Hansen, Henrik C., Young, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877016/
https://www.ncbi.nlm.nih.gov/pubmed/24391744
http://dx.doi.org/10.1371/journal.pone.0083190

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