Disrupting the Interaction between Retinoblastoma Protein and Raf-1 Leads to Defects in Progenitor Cell Proliferation and Survival during Early Inner Ear Development

The retinoblastoma protein (pRb) is required for cell-cycle exit of embryonic mammalian hair cells but is not required for hair cell fate determination and early differentiation, and this provides a strategy for hair cell regeneration by manipulating the pRb pathway. To reveal the mechanism of pRb f...

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Detalles Bibliográficos
Autores principales: Li, Wenyan, Sun, Shan, Chen, Yan, Yu, Huiqian, Chen, Zheng-Yi, Li, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877085/
https://www.ncbi.nlm.nih.gov/pubmed/24391814
http://dx.doi.org/10.1371/journal.pone.0083726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877085/
https://www.ncbi.nlm.nih.gov/pubmed/24391814
http://dx.doi.org/10.1371/journal.pone.0083726

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