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Loss of aPKCλ in Differentiated Neurons Disrupts the Polarity Complex but Does Not Induce Obvious Neuronal Loss or Disorientation in Mouse Brains
Cell polarity plays a critical role in neuronal differentiation during development of the central nervous system (CNS). Recent studies have established the significance of atypical protein kinase C (aPKC) and its interacting partners, which include PAR-3, PAR-6 and Lgl, in regulating cell polarizati...
Autores principales: | Yamanaka, Tomoyuki, Tosaki, Asako, Kurosawa, Masaru, Akimoto, Kazunori, Hirose, Tomonori, Ohno, Shigeo, Hattori, Nobutaka, Nukina, Nobuyuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877147/ https://www.ncbi.nlm.nih.gov/pubmed/24391875 http://dx.doi.org/10.1371/journal.pone.0084036 |
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