Cargando…
Regulation of the unfolded protein response by microRNAs
The unfolded protein response (UPR) is an adaptive response to the stress that is caused by an accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER). It is an important component of cellular homeostasis. During ER stress, the UPR increases the protein-folding capacity of...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877167/ https://www.ncbi.nlm.nih.gov/pubmed/24092331 http://dx.doi.org/10.2478/s11658-013-0106-z |
_version_ | 1782297605895618560 |
---|---|
author | Bartoszewska, Sylwia Kochan, Kinga Madanecki, Piotr Piotrowski, Arkadiusz Ochocka, Renata Collawn, James F. Bartoszewski, Rafal |
author_facet | Bartoszewska, Sylwia Kochan, Kinga Madanecki, Piotr Piotrowski, Arkadiusz Ochocka, Renata Collawn, James F. Bartoszewski, Rafal |
author_sort | Bartoszewska, Sylwia |
collection | PubMed |
description | The unfolded protein response (UPR) is an adaptive response to the stress that is caused by an accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER). It is an important component of cellular homeostasis. During ER stress, the UPR increases the protein-folding capacity of the endoplasmic reticulum to relieve the stress. Failure to recover leads to apoptosis. Specific cellular mechanisms are required for the cellular recovery phase after UPR activation. Using bioinformatics tools, we identified a number of microRNAs that are predicted to decrease the mRNA expression levels for a number of critical components of the UPR. In this review, we discuss the potential role of microRNAs as key regulators of this pathway and describe how microRNAs may play an essential role in turning off the UPR after the stress has subsided. |
format | Online Article Text |
id | pubmed-3877167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-38771672013-12-31 Regulation of the unfolded protein response by microRNAs Bartoszewska, Sylwia Kochan, Kinga Madanecki, Piotr Piotrowski, Arkadiusz Ochocka, Renata Collawn, James F. Bartoszewski, Rafal Cell Mol Biol Lett Review The unfolded protein response (UPR) is an adaptive response to the stress that is caused by an accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER). It is an important component of cellular homeostasis. During ER stress, the UPR increases the protein-folding capacity of the endoplasmic reticulum to relieve the stress. Failure to recover leads to apoptosis. Specific cellular mechanisms are required for the cellular recovery phase after UPR activation. Using bioinformatics tools, we identified a number of microRNAs that are predicted to decrease the mRNA expression levels for a number of critical components of the UPR. In this review, we discuss the potential role of microRNAs as key regulators of this pathway and describe how microRNAs may play an essential role in turning off the UPR after the stress has subsided. Springer Vienna 2013-10-02 /pmc/articles/PMC3877167/ /pubmed/24092331 http://dx.doi.org/10.2478/s11658-013-0106-z Text en © Versita Warsaw and Springer-Verlag Wien 2013 |
spellingShingle | Review Bartoszewska, Sylwia Kochan, Kinga Madanecki, Piotr Piotrowski, Arkadiusz Ochocka, Renata Collawn, James F. Bartoszewski, Rafal Regulation of the unfolded protein response by microRNAs |
title | Regulation of the unfolded protein response by microRNAs |
title_full | Regulation of the unfolded protein response by microRNAs |
title_fullStr | Regulation of the unfolded protein response by microRNAs |
title_full_unstemmed | Regulation of the unfolded protein response by microRNAs |
title_short | Regulation of the unfolded protein response by microRNAs |
title_sort | regulation of the unfolded protein response by micrornas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877167/ https://www.ncbi.nlm.nih.gov/pubmed/24092331 http://dx.doi.org/10.2478/s11658-013-0106-z |
work_keys_str_mv | AT bartoszewskasylwia regulationoftheunfoldedproteinresponsebymicrornas AT kochankinga regulationoftheunfoldedproteinresponsebymicrornas AT madaneckipiotr regulationoftheunfoldedproteinresponsebymicrornas AT piotrowskiarkadiusz regulationoftheunfoldedproteinresponsebymicrornas AT ochockarenata regulationoftheunfoldedproteinresponsebymicrornas AT collawnjamesf regulationoftheunfoldedproteinresponsebymicrornas AT bartoszewskirafal regulationoftheunfoldedproteinresponsebymicrornas |