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Sparsity as Cellular Objective to Infer Directed Metabolic Networks from Steady-State Metabolome Data: A Theoretical Analysis
Since metabolome data are derived from the underlying metabolic network, reverse engineering of such data to recover the network topology is of wide interest. Lyapunov equation puts a constraint to the link between data and network by coupling the covariance of data with the strength of interactions...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877278/ https://www.ncbi.nlm.nih.gov/pubmed/24391961 http://dx.doi.org/10.1371/journal.pone.0084505 |