Identification of Adaptive Mutations in the Influenza A Virus Non-Structural 1 Gene That Increase Cytoplasmic Localization and Differentially Regulate Host Gene Expression

The NS1 protein of influenza A virus (IAV) is a multifunctional virulence factor. We have previously characterized gain-of-function mutations in the NS1 protein arising from the experimental adaptation of the human isolate A/Hong Kong/1/1968(H3N2) (HK) to the mouse. The majority of these mouse adapt...

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Detalles Bibliográficos
Autores principales: Forbes, Nicole, Selman, Mohammed, Pelchat, Martin, Jia, Jian Jun, Stintzi, Alain, Brown, Earl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877356/
https://www.ncbi.nlm.nih.gov/pubmed/24391972
http://dx.doi.org/10.1371/journal.pone.0084673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877356/
https://www.ncbi.nlm.nih.gov/pubmed/24391972
http://dx.doi.org/10.1371/journal.pone.0084673

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