The MEK/ERK Pathway Promotes NOTCH Signalling in Pancreatic Cancer Cells

Activation of the NOTCH receptors relies on their intracellular proteolysis by the gamma-secretase complex. This cleavage liberates the NOTCH intracellular domain (NIC) thereby allowing the translocation of NIC towards the nucleus to assemble into a transcriptional platform. Little information is av...

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Detalles Bibliográficos
Autores principales: Tremblay, Isabelle, Paré, Emanuel, Arsenault, Dominique, Douziech, Mélanie, Boucher, Marie-Josée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877363/
https://www.ncbi.nlm.nih.gov/pubmed/24392017
http://dx.doi.org/10.1371/journal.pone.0085502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877363/
https://www.ncbi.nlm.nih.gov/pubmed/24392017
http://dx.doi.org/10.1371/journal.pone.0085502

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