Human A53T α-Synuclein Causes Reversible Deficits in Mitochondrial Function and Dynamics in Primary Mouse Cortical Neurons

Parkinson’s disease (PD) is the second most common neurodegenerative disease. A key pathological feature of PD is Lewy bodies, of which the major protein component is α-synuclein (α-syn). Human genetic studies have shown that mutations (A53T, A30P, E46K) and multiplication of the α-syn gene are link...

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Detalles Bibliográficos
Autores principales: Li, Li, Nadanaciva, Sashi, Berger, Zdenek, Shen, Wei, Paumier, Katrina, Schwartz, Joel, Mou, Kewa, Loos, Paula, Milici, Anthony J., Dunlop, John, Hirst, Warren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877382/
https://www.ncbi.nlm.nih.gov/pubmed/24392030
http://dx.doi.org/10.1371/journal.pone.0085815

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