Arsenic Trioxide Overcomes Rapamycin-Induced Feedback Activation of AKT and ERK Signaling to Enhance the Anti-Tumor Effects in Breast Cancer

Inhibitors of the mammalian target of rapamycin (mTORi) have clinical activity; however, the benefits of mTOR inhibition by rapamycin and rapamycin-derivatives (rapalogs) may be limited by a feedback mechanism that results in AKT activation. Increased AKT activity resulting from mTOR inhibition can...

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Detalles Bibliográficos
Autores principales: Guilbert, Cynthia, Annis, Matthew G., Dong, Zhifeng, Siegel, Peter M., Miller, Wilson H., Mann, Koren K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877392/
https://www.ncbi.nlm.nih.gov/pubmed/24392034
http://dx.doi.org/10.1371/journal.pone.0085995

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