Targeting HSP90 and monoclonal protein trafficking modulates the unfolded protein response, chaperone regulation and apoptosis in myeloma cells

Multiple myeloma is characterized by the production of substantial quantities of monoclonal protein. We have previously demonstrated that select inhibitors of the isoprenoid biosynthetic pathway (IBP) induce apoptosis of myeloma cells via inhibition of Rab geranylgeranylation, leading to disruption...

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Detalles Bibliográficos
Autores principales: Born, E J, Hartman, S V, Holstein, S A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877421/
https://www.ncbi.nlm.nih.gov/pubmed/24317089
http://dx.doi.org/10.1038/bcj.2013.64

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877421/
https://www.ncbi.nlm.nih.gov/pubmed/24317089
http://dx.doi.org/10.1038/bcj.2013.64

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