Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

T-cell large granular lymphocytic (T-LGL) leukemia is a clonal disease characterized by the expansion of mature CD3+CD8+ cytotoxic T cells. It is often associated with autoimmune disorders and immune-mediated cytopenias. Our recent findings suggest that up to 40% of T-LGL patients harbor mutations i...

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Detalles Bibliográficos
Autores principales: Andersson, E I, Rajala, H L M, Eldfors, S, Ellonen, P, Olson, T, Jerez, A, Clemente, M J, Kallioniemi, O, Porkka, K, Heckman, C, Loughran, T P, Maciejewski, J P, Mustjoki, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877422/
https://www.ncbi.nlm.nih.gov/pubmed/24317090
http://dx.doi.org/10.1038/bcj.2013.65

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