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Sensitive Fluorometric Method for the Determination of Rutin in Combined Tablet Dosage Form
A sensitive method based on the fluorescence enhancement was developed for the determination of rutin. It was found that the rutin could form a fluorescent complex with ytterium (III), and the fluorescence intensity of which could be enhanced by sodium dodecyl benzene sulfonate. Under the optimum co...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877527/ https://www.ncbi.nlm.nih.gov/pubmed/24403666 |
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author | Liu, S. F. |
author_facet | Liu, S. F. |
author_sort | Liu, S. F. |
collection | PubMed |
description | A sensitive method based on the fluorescence enhancement was developed for the determination of rutin. It was found that the rutin could form a fluorescent complex with ytterium (III), and the fluorescence intensity of which could be enhanced by sodium dodecyl benzene sulfonate. Under the optimum conditions, the enhanced fluorescence intensity was in proportion to the concentration of rutin in the range of 12-1200 ng/ml and the detection limit (S/N=3) was 1.3 ng/ml. This method possessed the properties of simplicity, fast assay process and high sensitivity, and has been satisfactorily applied for the analysis of actual sample. The possible interaction mechanism of this system was also discussed in this manuscript. |
format | Online Article Text |
id | pubmed-3877527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38775272014-01-08 Sensitive Fluorometric Method for the Determination of Rutin in Combined Tablet Dosage Form Liu, S. F. Indian J Pharm Sci Short Communication A sensitive method based on the fluorescence enhancement was developed for the determination of rutin. It was found that the rutin could form a fluorescent complex with ytterium (III), and the fluorescence intensity of which could be enhanced by sodium dodecyl benzene sulfonate. Under the optimum conditions, the enhanced fluorescence intensity was in proportion to the concentration of rutin in the range of 12-1200 ng/ml and the detection limit (S/N=3) was 1.3 ng/ml. This method possessed the properties of simplicity, fast assay process and high sensitivity, and has been satisfactorily applied for the analysis of actual sample. The possible interaction mechanism of this system was also discussed in this manuscript. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3877527/ /pubmed/24403666 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-accessa rticle distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Liu, S. F. Sensitive Fluorometric Method for the Determination of Rutin in Combined Tablet Dosage Form |
title | Sensitive Fluorometric Method for the Determination of Rutin in Combined Tablet Dosage Form |
title_full | Sensitive Fluorometric Method for the Determination of Rutin in Combined Tablet Dosage Form |
title_fullStr | Sensitive Fluorometric Method for the Determination of Rutin in Combined Tablet Dosage Form |
title_full_unstemmed | Sensitive Fluorometric Method for the Determination of Rutin in Combined Tablet Dosage Form |
title_short | Sensitive Fluorometric Method for the Determination of Rutin in Combined Tablet Dosage Form |
title_sort | sensitive fluorometric method for the determination of rutin in combined tablet dosage form |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877527/ https://www.ncbi.nlm.nih.gov/pubmed/24403666 |
work_keys_str_mv | AT liusf sensitivefluorometricmethodforthedeterminationofrutinincombinedtabletdosageform |