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Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors

Leukemia stem cells (LSCs) are considered to be the main reason for relapse and are also regarded as a major hurdle for the success of acute myeloid leukemia chemotherapy. Thus, new drugs targeting LSCs are urgently needed. Triptolide (TPL) is cytotoxic to LSCs. Low dose of TPL enhances the cytotoxi...

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Detalles Bibliográficos
Autores principales:	Liu, Y, Chen, F, Wang, S, Guo, X, Shi, P, Wang, W, Xu, B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877540/ https://www.ncbi.nlm.nih.gov/pubmed/24309935 http://dx.doi.org/10.1038/cddis.2013.467

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