Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

Much effort has been put in the discovery of ways to selectively kill p53-deficient tumor cells and targeting cell cycle checkpoint pathways has revealed promising candidates. Studies in zebrafish and human cell lines suggested that the DNA damage response kinase, checkpoint kinase 1 (Chk1), not onl...

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Detalles Bibliográficos
Autores principales: Manzl, C, Fava, L L, Krumschnabel, G, Peintner, L, Tanzer, M C, Soratroi, C, Bock, F J, Schuler, F, Luef, B, Geley, S, Villunger, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877543/
https://www.ncbi.nlm.nih.gov/pubmed/24309929
http://dx.doi.org/10.1038/cddis.2013.470

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