A candidate anti-HIV reservoir compound, auranofin, exerts a selective ‘anti-memory' effect by exploiting the baseline oxidative status of lymphocytes

Central memory (T(CM)) and transitional memory (T(TM)) CD4(+) T cells are known to be the major cellular reservoirs for HIV, as these cells can harbor a transcriptionally silent form of viral DNA that is not targeted by either the immune system or current antiretroviral drug regimens. In the present...

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Detalles Bibliográficos
Autores principales: Chirullo, B, Sgarbanti, R, Limongi, D, Shytaj, I L, Alvarez, D, Das, B, Boe, A, DaFonseca, S, Chomont, N, Liotta, L, III Petricoin, E, Norelli, S, Pelosi, E, Garaci, E, Savarino, A, Palamara, A T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877546/
https://www.ncbi.nlm.nih.gov/pubmed/24309931
http://dx.doi.org/10.1038/cddis.2013.473

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