Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation

Cultured human umbilical cord mesenchymal stem cells (hUC-MSCs) are being tested in several clinical trials and encouraging outcomes have been observed. To determine whether in vitro expansion influences the genomic stability of hUC-MSCs, we maintained nine hUC-MSC clones in long-term culture and co...

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Detalles Bibliográficos
Autores principales: Wang, Y, Zhang, Z, Chi, Y, Zhang, Q, Xu, F, Yang, Z, Meng, L, Yang, S, Yan, S, Mao, A, Zhang, J, Yang, Y, Wang, S, Cui, J, Liang, L, Ji, Y, Han, Z-B, Fang, X, Han, Z C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877551/
https://www.ncbi.nlm.nih.gov/pubmed/24309937
http://dx.doi.org/10.1038/cddis.2013.480

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