Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway

Chemotherapy remains the common therapeutic for patients with lung cancer. Novel, selective antitumor agents are pressingly needed. This study is the first to investigate a different, however, effective antitumor drug candidate Wentilactone A (WA) for its development as a novel agent. In NCI-H460 an...

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Detalles Bibliográficos
Autores principales: Lv, C, Hong, Y, Miao, L, Li, C, Xu, G, Wei, S, Wang, B, Huang, C, Jiao, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877555/
https://www.ncbi.nlm.nih.gov/pubmed/24309939
http://dx.doi.org/10.1038/cddis.2013.484

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