In serum veritas—in serum sanitas? Cell non-autonomous aging compromises differentiation and survival of mesenchymal stromal cells via the oxidative stress pathway

Even tissues capable of complete regeneration, such as bone, show an age-related reduction in their healing capacity. Here, we hypothesized that this decline is primarily due to cell non-autonomous (extrinsic) aging mediated by the systemic environment. We demonstrate that culture of mesenchymal str...

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Detalles Bibliográficos
Autores principales: Geißler, S, Textor, M, Schmidt-Bleek, K, Klein, O, Thiele, M, Ellinghaus, A, Jacobi, D, Ode, A, Perka, C, Dienelt, A, Klose, J, Kasper, G, Duda, G N, Strube, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877568/
https://www.ncbi.nlm.nih.gov/pubmed/24357801
http://dx.doi.org/10.1038/cddis.2013.501

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