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Anomalous Left Main Coronary Artery: Case Series of Different Courses and Literature Review

Background. Congenital anomalies of the coronary arteries are a cause of sudden cardiac death. Of the known anatomic variants, anomalous origination of a coronary artery from an opposite sinus of Valsalva (ACAOS) remains the main focus of debate. Case Series. We present three cases, all presenting t...

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Autores principales: Marler, Adam T., Malik, Jamil A., Slim, Ahmad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877606/
https://www.ncbi.nlm.nih.gov/pubmed/24455397
http://dx.doi.org/10.1155/2013/380952
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author Marler, Adam T.
Malik, Jamil A.
Slim, Ahmad M.
author_facet Marler, Adam T.
Malik, Jamil A.
Slim, Ahmad M.
author_sort Marler, Adam T.
collection PubMed
description Background. Congenital anomalies of the coronary arteries are a cause of sudden cardiac death. Of the known anatomic variants, anomalous origination of a coronary artery from an opposite sinus of Valsalva (ACAOS) remains the main focus of debate. Case Series. We present three cases, all presenting to our facility within one week's time, of patients with newly discovered anomalous origination of the left coronary artery from the right sinus of Valsalva (L-ACAOS). All patients underwent cardiac computed tomography for evaluation of coronary anatomy along with other forms of functional testing. Despite the high risk nature of two of the anomalies, the patients are being treated medically without recurrence of symptoms. Summary. After review of the literature, we have found that the risk of sudden cardiac death in patients with congenital coronary anomalies, even among variants considered the highest risk, may be overestimated. In addition, the exact prevalence of coronary anomalies in the general population is currently underestimated. A national coronary artery anomaly registry based on cardiac computed tomography and invasive coronary angiography data would be helpful in advancing our understanding of these cardiac peculiarities. The true prevalence of congenital coronary anomalies and overall risk of sudden cardiac death in this population are not well known. Surgical intervention remains the mainstay of therapy in certain patients though recent investigations into the pathophysiology of these abnormalities have shown that the risk of surgery may outweigh the minimal reduction in risk of sudden cardiac death.
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spelling pubmed-38776062014-01-16 Anomalous Left Main Coronary Artery: Case Series of Different Courses and Literature Review Marler, Adam T. Malik, Jamil A. Slim, Ahmad M. Case Rep Vasc Med Case Report Background. Congenital anomalies of the coronary arteries are a cause of sudden cardiac death. Of the known anatomic variants, anomalous origination of a coronary artery from an opposite sinus of Valsalva (ACAOS) remains the main focus of debate. Case Series. We present three cases, all presenting to our facility within one week's time, of patients with newly discovered anomalous origination of the left coronary artery from the right sinus of Valsalva (L-ACAOS). All patients underwent cardiac computed tomography for evaluation of coronary anatomy along with other forms of functional testing. Despite the high risk nature of two of the anomalies, the patients are being treated medically without recurrence of symptoms. Summary. After review of the literature, we have found that the risk of sudden cardiac death in patients with congenital coronary anomalies, even among variants considered the highest risk, may be overestimated. In addition, the exact prevalence of coronary anomalies in the general population is currently underestimated. A national coronary artery anomaly registry based on cardiac computed tomography and invasive coronary angiography data would be helpful in advancing our understanding of these cardiac peculiarities. The true prevalence of congenital coronary anomalies and overall risk of sudden cardiac death in this population are not well known. Surgical intervention remains the mainstay of therapy in certain patients though recent investigations into the pathophysiology of these abnormalities have shown that the risk of surgery may outweigh the minimal reduction in risk of sudden cardiac death. Hindawi Publishing Corporation 2013 2013-12-22 /pmc/articles/PMC3877606/ /pubmed/24455397 http://dx.doi.org/10.1155/2013/380952 Text en Copyright © 2013 Adam T. Marler et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Marler, Adam T.
Malik, Jamil A.
Slim, Ahmad M.
Anomalous Left Main Coronary Artery: Case Series of Different Courses and Literature Review
title Anomalous Left Main Coronary Artery: Case Series of Different Courses and Literature Review
title_full Anomalous Left Main Coronary Artery: Case Series of Different Courses and Literature Review
title_fullStr Anomalous Left Main Coronary Artery: Case Series of Different Courses and Literature Review
title_full_unstemmed Anomalous Left Main Coronary Artery: Case Series of Different Courses and Literature Review
title_short Anomalous Left Main Coronary Artery: Case Series of Different Courses and Literature Review
title_sort anomalous left main coronary artery: case series of different courses and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877606/
https://www.ncbi.nlm.nih.gov/pubmed/24455397
http://dx.doi.org/10.1155/2013/380952
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